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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Cadenas, C; Vosbeck, S; Edlund, K; Grgas, K; Madjar, K; Hellwig, B; Adawy, A; Glotzbach, A; Stewart, JD; Lesjak, MS; Franckenstein, D; Claus, M; Hayen, H; Schriewer, A; Gianmoena, K; Thaler, S; Schmidt, M; Micke, P; Pontén, F; Mardinoglu, A; Zhang, C; Käfferlein, HU; Watzl, C; Frank, S; Rahnenführer, J; Marchan, R; Hengstler, JG.
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.
Int J Cancer. 2019; 145(4): 901-915. Doi: 10.1002/ijc.32138 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
Frank Sasa
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Abstract:
Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that severe oxidative stress leading to AMPK activation triggers LIPG upregulation, resulting in intracellular lipid droplet accumulation in breast cancer cells, which supports survival. Neutralizing oxidative stress abrogated LIPG upregulation and the concomitant lipid storage. In human breast cancer, high LIPG expression was observed in a limited subset of tumours and was significantly associated with shorter metastasis-free survival in node-negative, untreated patients. Moreover, expression of PLIN2 and TXNRD1 in these tumours indicated a link to lipid storage and oxidative stress. Altogether, our findings reveal a previously unrecognized role for LIPG in enabling oxidative stress-induced lipid droplet accumulation in tumour cells that protects against oxidative stress, and thus supports tumour progression. © 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

Find related publications in this database (Keywords)
breast cancer
endothelial lipase
LIPG
lipid droplets
oxidative stress
PLIN2
TXNRD1
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