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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Groschner, K; Tiapko, O.
Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture.
Cell Calcium. 2018; 74(9):144-146
Doi: 10.1016/j.ceca.2018.07.006
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Groschner Klaus
- Co-Autor*innen der Med Uni Graz
- Tiapko Oleksandra
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- Abstract:
- Canonical TRP channels (TRPCs) are a particularly enigmatic family of signaling molecules with multimodal sensing features, being involved in a wide range of biological functions. Until very recently, the main hurdle towards comprehensive mechanistic understanding of TRPC signaling has been the lack of structural information. This has changed early this year by several reports on TRPC architectures resolved by single particle cryo-EM analysis. These studies confirmed recently elaborated concepts on TRPC structure-function relations, and unveiled unanticipated features and complexity in the TRPC sensing machinery. Copyright © 2018 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Binding Sites - physiology
- Humans -
- Molecular Structure -
- Signal Transduction - physiology
- TRPC Cation Channels - chemistry
- TRPC Cation Channels - metabolism
- Find related publications in this database (Keywords)
- TRPC channels
- Cryo-EM
- Gating machinery
- Molecular architecture