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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Graffmann, N; Bohndorf, M; Ncube, A; Wruck, W; Kashofer, K; Zatloukal, K; Adjaye, J.
Establishment and characterization of an iPSC line from a 58 years old high grade patient with nonalcoholic fatty liver disease (70% steatosis) with homozygous wildtype PNPLA3 genotype.
Stem Cell Res. 2018; 31(4):131-134
Doi: 10.1016/j.scr.2018.07.011
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- Co-Autor*innen der Med Uni Graz
- Kashofer Karl
- Zatloukal Kurt
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- Abstract:
- Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and its prevalence increases continuously. Here, we reprogrammed fibroblasts of a high grade NAFLD patient with homozygous wildtype PNPLA3 genotype. We characterized the induced pluripotent stem cells (iPSCs) by immunocytochemistry, flow cytometry, embryoid body formation, pluritest DNA-fingerprinting, and karyotype analysis. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Genotype -
- Homozygote -
- Humans -
- Induced Pluripotent Stem Cells - metabolism
- Lipase - genetics
- Membrane Proteins - genetics
- Middle Aged -
- Non-alcoholic Fatty Liver Disease - genetics
- Non-alcoholic Fatty Liver Disease - pathology