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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Graffmann, N; Bohndorf, M; Ncube, A; Kawala, MA; Wruck, W; Kashofer, K; Zatloukal, K; Adjaye, J.
Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype.
Stem Cell Res. 2018; 31: 113-116.
Doi: 10.1016/j.scr.2018.07.015
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- Co-Autor*innen der Med Uni Graz
- Kashofer Karl
- Zatloukal Kurt
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- Abstract:
- Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and its prevalence increases continuously. Here, we reprogrammed fibroblasts of a high grade NAFLD patient with homozygous wildtype PNPLA3 genotype. The induced pluripotent stem cells (iPSCs) were characterized by immunocytochemistry, flow cytometry, embryoid body formation, pluritest, DNA-fingerprinting and karyotype analysis. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.