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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weber, P; Nasseri, SA; Pabst, BM; Torvisco, A; Müller, P; Paschke, E; Tschernutter, M; Windischhofer, W; Withers, SG; Wrodnigg, TM; Stütz, AE.
Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols.
Molecules. 2018; 23(3): 708
Doi: 10.3390/molecules23030708
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- Co-Autor*innen der Med Uni Graz
- Pabst Bettina
- Paschke Eduard
- Tschernutter Marion
- Windischhofer Werner
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- Abstract:
- From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo.
- Find related publications in this database (Keywords)
- aminocyclopentane
- N-acetyl-D-hexosaminidase inhibitor
- Tay-Sachs