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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fuchs, CD; Claudel, T; Scharnagl, H; Stojakovic, T; Trauner, M.
FXR controls CHOP expression in steatohepatitis.
FEBS Lett. 2017; 591(20):3360-3368
Doi: 10.1002/1873-3468.12845
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- Führende Autor*innen der Med Uni Graz
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Claudel Thierry
- Scharnagl Hubert
- Stojakovic Tatjana
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- Abstract:
- The farnesoid X receptor (FXR) and C/EBP homologous protein (CHOP) have critical functions in hepatic lipid metabolism. Here, we aimed to explore a potential relationship between FXR and CHOP. We fed wild-type (WT) and FXR KO mice a MCD diet (model of steatohepatitis) and found that Chop mRNA expression is upregulated in WT but not FXR KO mice. The absence of FXR aggravates hepatic inflammation after MCD feeding. In HepG2 cells, we found that Chop expression is regulated in a FXR/Retinoid X receptor (RXR)-dependent manner. We identified a FXR/RXR-binding site in the human CHOP promoter, demonstrating a highly conserved regulatory pathway. Our study shows that FXR/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder. © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Binding Sites -
- Chenodeoxycholic Acid - pharmacology
- Diet, High-Fat -
- Disease Models, Animal -
- Gene Expression Regulation -
- Glucose - pharmacology
- Hep G2 Cells -
- Humans -
- Lipid Metabolism - drug effects
- Liver - drug effects
- Liver - metabolism
- Liver - pathology
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Non-alcoholic Fatty Liver Disease - etiology
- Non-alcoholic Fatty Liver Disease - genetics
- Non-alcoholic Fatty Liver Disease - metabolism
- Non-alcoholic Fatty Liver Disease - pathology
- Promoter Regions, Genetic -
- Protein Binding -
- RNA, Messenger - genetics
- RNA, Messenger - metabolism
- Receptors, Cytoplasmic and Nuclear - genetics
- Receptors, Cytoplasmic and Nuclear - metabolism
- Retinoid X Receptors - genetics
- Retinoid X Receptors - metabolism
- Signal Transduction -
- Transcription Factor CHOP - genetics
- Transcription Factor CHOP - metabolism
- Tretinoin - pharmacology
- Find related publications in this database (Keywords)
- inflammation
- nonalcoholic fatty liver disease (NAFLD)
- nonalcoholic steatohepatitis (NASH)
- nuclear receptor