Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

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Potočnjak, I; Trbušić, M; Terešak, SD; Radulović, B; Pregartner, G; Berghold, A; Tiran, B; Marsche, G; Degoricija, V; Frank, S.
Metabolic Syndrome Modulates Association between Endothelial Lipase and Lipid/Lipoprotein Plasma Levels in Acute Heart Failure Patients.
Sci Rep. 2017; 7(1):1165-1165 Doi: 10.1038/s41598-017-01367-2 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: Frank Sasa
Co-Autor*innen der Med Uni Graz: Berghold Andrea; Marsche Gunther; Pregartner Gudrun; Tiran Beate
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Abstract:: We hypothesised that the established association of endothelial lipase (EL) plasma levels with atherogenic lipid profile is altered in acute heart failure (AHF) and additionally affected by overlapping metabolic syndrome (MetS). We examined the association of EL plasma levels and lipid/lipoprotein plasma levels in AHF patients without and with overlapping MetS. The study was performed as a single-centre, observational study on 152 AHF patients, out of which 85 had overlapping MetS. In the no-MetS group, EL plasma levels were significantly positively correlated with plasma levels of atherogenic lipids/lipoproteins, including total cholesterol, low-density lipoprotein (LDL)-cholesterol, total LDL particles and triglycerides, but also with plasma levels of antiatherogenic high-density lipoprotein (HDL)-cholesterol, total HDL particles and small HDL particles. In the MetS group, EL plasma levels were positively correlated with triglyceride and small LDL-particle levels, and significantly negatively correlated with plasma levels of large HDL particles as well as with LDL- and HDL-particle size, respectively. EL- and lipid/lipoprotein- plasma levels were different in the no-MetS patients, compared to MetS patients. The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Female -; Heart Failure - complications; Heart Failure - pathology; Humans -; Lipase - blood; Lipids - blood; Lipoproteins - blood; Male -; Metabolic Syndrome - complications; Middle Aged -; Plasma - chemistry; Plasma - enzymology