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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Paternostro, R; Wagner, D; Reiberger, T; Mandorfer, M; Schwarzer, R; Ferlitsch, M; Trauner, M; Peck-Radosavljevic, M; Ferlitsch, A.
Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis.
Wien Klin Wochenschr. 2017; 129(1-2):8-15
Doi: 10.1007/s00508-016-1127-1
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- Co-Autor*innen der Med Uni Graz
- Trauner Michael
- Wagner Doris
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- Abstract:
- Vitamin D deficiency is frequent in patients with cirrhosis. The aims of this study were to evaluate the relation of vitamin D status to portal hypertension, degree of liver dysfunction and survival. Patients with cirrhosis who have been tested for 25-OH-vitamin D levels were retrospectively included. Vitamin D deficiency was defined as 25-OH-vitamin D levels <10 ng/ml. Child-Pugh score, model for end-stage liver disease (MELD) and available hepatic venous pressure gradient (HVPG) were recorded. Mortality was documented during follow-up. A total of 199 patients were included. Prevalence of vitamin D deficiency (<10 ng/ml) was 40% (79/199), with 14% in Child-Pugh stage A, 39% in Child-Pugh stage B and 47% in Child-Pugh stage C (p = 0.001). Vitamin D deficiency was more common in patients with clinically significant portal hypertension (CSPH, HVPG ≥ 10 mm Hg) than in patients without (43.5% vs. 24.4%, p = 0.025). Significantly more deaths were observed in patients with vitamin D deficiency (32.9%, 26/79 vs. 13.3%, 16/120; p = 0.001). COX regression found presence of hepatocellular carcinoma (p < 0.001; HR: 5.763 95%CI:2.183-15.213), presence of CSPH (p = 0.026; HR: 5.487 95%CI: 1.226-24.55) and Child-Pugh stage C (p = 0.003; HR:5.429 95%CI: 1.771-16.638) as independent risk factors for mortality. Furthermore we could show a tendency towards group vitamin D deficiency being an independent risk factor (p = 0.060; HR: 1.86 95%CI:0.974-3.552). Vitamin D levels progressively decrease in more advanced Child stages and in patients with increasing HVPG. Vitamin D deficiency might be a valuable predictor of mortality in cirrhosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Distribution -
- Aged -
- Austria - epidemiology
- Biomarkers - blood
- Comorbidity -
- Female -
- Hepatic Insufficiency - blood
- Hepatic Insufficiency - diagnosis
- Hepatic Insufficiency - mortality
- Humans -
- Liver Cirrhosis - blood
- Liver Cirrhosis - diagnosis
- Liver Cirrhosis - mortality
- Liver Function Tests - statistics & numerical data
- Male -
- Middle Aged -
- Prevalence -
- Prognosis -
- Reproducibility of Results -
- Risk Factors -
- Sensitivity and Specificity -
- Sex Distribution -
- Survival Rate -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D Deficiency - blood
- Vitamin D Deficiency - mortality
- Find related publications in this database (Keywords)
- Vitamin D
- Cirrhosis
- Mortality
- Liver dysfunction
- Portal hypertension