Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grabner, GF; Zimmermann, R; Schicho, R; Taschler, U.
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.
Pharmacol Ther. 2017; 175:35-46
Doi: 10.1016/j.pharmthera.2017.02.033
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Grabner Gernot
- Schicho Rudolf
- Co-Autor*innen der Med Uni Graz
- Taschler Ulrike
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Monoglyerides (MGs) are short-lived, intermediary lipids deriving from the degradation of phospho- and neutral lipids, and monoglyceride lipase (MGL), also designated as monoacylglycerol lipase (MAGL), is the major enzyme catalyzing the hydrolysis of MGs into glycerol and fatty acids. This distinct function enables MGL to regulate a number of physiological and pathophysiological processes since both MGs and fatty acids can act as signaling lipids or precursors thereof. The most prominent MG species acting as signaling lipid is 2-arachidonoyl glycerol (2-AG) which is the most abundant endogenous agonist of cannabinoid receptors in the body. Importantly, recent observations demonstrate that 2-AG represents a quantitatively important source for arachidonic acid, the precursor of prostaglandins and other inflammatory mediators. Accordingly, MGL-mediated 2-AG degradation affects lipid signaling by cannabinoid receptor-dependent and independent mechanisms. Recent genetic and pharmacological studies gave important insights into MGL's role in (patho-)physiological processes, and the enzyme is now considered as a promising drug target for a number of disorders including cancer, neurodegenerative and inflammatory diseases. This review summarizes the basics of MG (2-AG) metabolism and provides an overview on the therapeutic potential of MGL.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Arachidonic Acids - metabolism
- Emotions - administration & dosage
- Endocannabinoids - metabolism
- Humans - administration & dosage
- Inflammation - metabolism
- Metabolic Diseases - metabolism
- Monoacylglycerol Lipases - metabolism
- Neoplasms - metabolism
- Pain - metabolism
- Signal Transduction - administration & dosage
- Stress, Physiological - administration & dosage
- Substance-Related Disorders - metabolism
- Find related publications in this database (Keywords)
- Monoglyceride lipase
- MGL
- MAGL
- 2-arachidonoyl glycerol
- Arachidonic acid
- Cannabinoid receptor
- Eicosanoids