Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Taschler, U; Hasenoehrl, C; Storr, M; Schicho, R.
Cannabinoid Receptors in Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.
Handb Exp Pharmacol. 2017; 239(6):343-362 Doi: 10.1007/164_2016_105
PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Taschler Ulrike
Co-Autor*innen der Med Uni Graz: Hasenöhrl Carina; Schicho Rudolf
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Abstract:: Cannabinoid receptors are fundamentally involved in all aspects of intestinal physiology, such as motility, secretion, and epithelial barrier function. They are part of a broader entity, the so-called endocannabinoid system which also includes their endocannabinoid ligands and the ligands' synthesizing/degrading enzymes. The system has a strong impact on the pathophysiology of the gastrointestinal tract and is believed to maintain homeostasis in the gut by controlling hypercontractility and by promoting regeneration after injury. For instance, genetic knockout of cannabinoid receptor 1 leads to inflammation and cancer of the intestines. Derivatives of Δ⁹-tetrahydrocannabinol, such as nabilone and dronabinol, activate cannabinoid receptors and have been introduced into the clinic to treat chemotherapy-induced emesis and loss of appetite; however, they may cause many psychotropic side effects. New drugs that interfere with endocannabinoid degradation to raise endocannabinoid levels circumvent this obstacle and could be used in the future to treat emesis, intestinal inflammation, and functional disorders associated with visceral hyperalgesia.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Endocannabinoids - metabolism; Gastric Juice - metabolism; Gastrointestinal Diseases - metabolism; Gastrointestinal Diseases - physiopathology; Gastrointestinal Motility -; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - physiopathology; Humans -; Intestinal Secretions - metabolism; Receptors, Cannabinoid - metabolism; Signal Transduction -