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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Meinitzer, A; Mangge, H; Kriegshäuser, G; Halwachs-Baumann, G; Reininghaus, EZ; Bengesser, SA; Schnedl, WJ.
Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.
Can J Gastroenterol Hepatol. 2016; 2016(2):4893501-4893501
Doi: 10.1155/2016/4893501
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Bengesser Susanne
- Kriegshäuser Gernot
- Mangge Harald
- Meinitzer Andreas
- Reininghaus Eva
- Schnedl Wolfgang
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- Abstract:
- The aim of this retrospective study was to analyze the concomitant prevalence rates for lactose malabsorption (LM), fructose malabsorption (FM), and histamine intolerance (HI) in patients with so far unexplained gastrointestinal (GI) symptoms. A total of 439 outpatients, who presented unclear abdominal discomfort, underwent lactose (50 g) and fructose (25 g) hydrogen (H2) breath tests. Additionally, serum diamine oxidase (DAO) measurements were performed. Individuals with low serum DAO activity (<10 U/mL), GI symptoms, and response to histamine-free diet were diagnosed with HI. Of all 439 patients, 341 (77.7%) were found with 7 various GI conditions. In total, 94 (21.4%), 31 (7.1%), and 100 (22.8%) individuals presented LM, FM, or HI only, whereas 116 (26.4%) patients showed an overlap of GI entities investigated here. Interestingly, 89 out of 241 (36.9%) individuals with carbohydrate malabsorption were also diagnosed with HI (LM + HI: 52 [11.8%], FM + HI: 23 [5.2%], and LM + FM + HI 14 [3.2%] individuals). In conclusion different combinations of LM, FM, and HI are present in individuals with unclear abdominal discomfort/pain. In clinical practice we suggest testing for LM, FM, and additional HI in the diagnostic work-up of these patients. Depending on these various diagnoses possible, patients should get an individualized dietary advice.
- Find related publications in this database (using NLM MeSH Indexing)
- Abdominal Pain - blood
- Abdominal Pain - diagnosis
- Abdominal Pain - etiology
- Adult -
- Amine Oxidase (Copper-Containing) - blood
- Breath Tests -
- Carbohydrates - analysis
- Diet -
- Female -
- Fructose - analysis
- Gastrointestinal Diseases - blood
- Gastrointestinal Diseases - complications
- Gastrointestinal Diseases - epidemiology
- Histamine - analysis
- Humans -
- Hydrogen - analysis
- Lactose - analysis
- Lactose Intolerance - complications
- Lactose Intolerance - diagnosis
- Malabsorption Syndromes - blood
- Malabsorption Syndromes - complications
- Male -
- Middle Aged -
- Prevalence -
- Retrospective Studies -