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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kleber, ME; Delgado, GE; Lorkowski, S; März, W; von Schacky, C.
Omega-3 fatty acids and mortality in patients referred for coronary angiography. The Ludwigshafen Risk and Cardiovascular Health Study.
Atherosclerosis. 2016; 252(3):175-181
Doi: 10.1016/j.atherosclerosis.2016.06.049
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Erythrocyte omega-3 fatty acid proportions were measured at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) using the HS-Omega-3 Index method. Associations of omega-3 fatty acid proportions with mortality were investigated using Cox proportional hazards regression. During a median follow-up of 9.9 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. Proportions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were inversely associated with all-cause and cardiovascular mortality in models adjusted for conventional cardiovascular risk factors. The strongest association was observed for EPA with a hazard ratio (HR) of 0.89 (0.83-0.96) per increase of one standard deviation. Furthermore, we obtained evidence for a non-linear relation between EPA and mortality. EPA and DHA were associated with reduced mortality in LURIC, independent of other risk factors, with the association of EPA with mortality being non-linear. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anthropometry -
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - diagnostic imaging
- Cardiovascular Diseases - mortality
- Coronary Angiography -
- Cross-Sectional Studies -
- Docosahexaenoic Acids - blood
- Eicosapentaenoic Acid - blood
- Fatty Acids, Omega-3 - blood
- Female -
- Follow-Up Studies -
- Germany -
- Humans -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Sex Factors -
- Find related publications in this database (Keywords)
- Omega-3 fatty acids
- Alpha-linolenic acid
- Eicosapentaenoic acid
- Docosahexaenoic acid
- Mortality