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Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Daniel Scherr

Gerhard Pichler

Roland Malli

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Kollerits, B; Drechsler, C; Krane, V; Lamina, C; März, W; Dieplinger, H; Ritz, E; Wanner, C; Kronenberg, F; German Diabetes and Dialysis Study Investigators.
Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study.
Nephrol Dial Transplant. 2016; 31(11):1901-1908 Doi: 10.1093/ndt/gfv428 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: März Winfried
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Abstract:: High lipoprotein(a) [Lp(a)] concentrations and low molecular weight (LMW) apolipoprotein(a) [apo(a)] isoforms are associated with cardiovascular disease and mortality in the general population. We examined the association of both with all-cause mortality and cardiovascular endpoints in haemodialysis patients with diabetes mellitus. This is a post hoc analysis of the prospective 4D Study (German Diabetes Dialysis Study) that evaluated atorvastatin compared with placebo in 1255 haemodialysis patients with type 2 diabetes mellitus (median follow-up 4 years). The association of natural logarithm-transformed Lp(a) concentrations (increment one unit) and apo(a) isoforms with outcomes was analysed by Cox proportional hazards regression. The influence of age (median 66 years) was evaluated by stratified survival analyses. The median baseline Lp(a) concentration was 11.5 mg/dL (IQR 5.0-41.8). A quarter of patients had at least one LMW apo(a) isoform. Increased Lp(a) concentrations were associated with all-cause mortality in the total group [hazard ratio (HR) 1.09 (95% CI 1.03-1.16), P = 0.004]. LMW apo(a) isoforms were only associated with all-cause mortality in patients ≤ 66 years [HR 1.38 (95% CI 1.05-1.80), P = 0.02]. The strongest association for Lp(a) concentrations and LMW apo(a) isoforms was found for death due to infection in patients ≤ 66 years [HR 1.39 (95% CI 1.14-1.71), P = 0.001; HR 2.17 (95% CI 1.26-3.75), P = 0.005]. Lp(a) concentrations were also associated with fatal stroke in patients ≤66 years of age [HR 1.54 (95% CI 1.05-2.24), P = 0.03]. Neither Lp(a) nor LMW apo(a) isoforms were associated with other atherosclerosis-related events. High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Aged, 80 and over -; Apoprotein(a) - blood; Atorvastatin Calcium - administration & dosage; Biomarkers - blood; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Cause of Death - trends; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - therapy; Dose-Response Relationship, Drug -; Double-Blind Method -; Female -; Follow-Up Studies -; Germany - epidemiology; Humans -; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage; Incidence -; Lipoprotein(a) - blood; Male -; Middle Aged -; Phenotype -; Prospective Studies -; Protein Isoforms -; Renal Dialysis -; Survival Rate - trends; Time Factors -; Young Adult -
Find related publications in this database (Keywords): all-cause mortality; apolipoprotein(a) isoforms; cardiovascular disease; diabetes mellitus; infection; lipoprotein(a)