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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leis, HJ; Windischhofer, W.
Ionomycin induces prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells via mechanisms independent of its ionophoric nature.
Biochem Cell Biol. 2016; 94(3):236-240
Doi: 10.1139/bcb-2015-0148
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- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Windischhofer Werner
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- Abstract:
- Ionomycin and A23187 are divalent cation ionophores with a marked preference for calcium. Studies using these ionophores have almost exclusively interpreted their results in the light of calcium elevation. It was the aim of this study to investigate the effects of ionomycin in osteoblatic MC3T3-E1 cells that are not attributable to its ionophoric properties. Thus, we have found that in contrast to A23187, ionomycin shows similar effects on prostaglandin E2 formation as bradykinin and endothelin-1, being potentiated by extracellular nickel and inhibited by cholera toxin and pertussis toxin. Our data strongly suggest that inomycin, at least in part, exerts its effects via specific binding to a G-protein coupled receptor, thereby evoking downstream cellular events like arachidonate release with subsequent prostaglandin formation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bradykinin - pharmacology
- Calcimycin - pharmacology
- Calcium - pharmacology
- Calcium Ionophores - pharmacology
- Cell Line -
- Cholera Toxin - pharmacology
- Dinoprostone - biosynthesis
- Dinoprostone - metabolism
- Ionomycin - pharmacology
- Mice -
- Nickel - pharmacology
- Osteoblasts - drug effects
- Osteoblasts - metabolism
- Pertussis Toxin - pharmacology
- Receptors, G-Protein-Coupled - metabolism
- Find related publications in this database (Keywords)
- ionomycin
- A23187
- prostaglandin
- nickel
- osteoblast
- MC3T3-E1