Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Besenboeck, C; Cvitic, S; Lang, U; Desoye, G; Wadsack, C.
Going into labor and beyond: phospholipase A2 in pregnancy.
Reproduction. 2016; 151(6):R91-R102 Doi: 10.1530/REP-15-0519 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Schliefsteiner Carolin
Wadsack Christian
Co-Autor*innen der Med Uni Graz
Desoye Gernot
Lang Uwe
Tokic Silvija
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
The phospholipase A2 (PLA2) family is a very diverse group of enzymes, all serving in the cleavage of phospholipids, thereby releasing high amounts of arachidonic acid (AA) and lysophospholipids. AA serves as a substrate for prostaglandin production, which is of special importance in pregnancy for the onset of parturition. Novel research demonstrates that PLA2 action affects the immune response of the mother toward the child and is therefore probably implied in the tolerance of the fetus and prevention of miscarriage. This review presents data on the biochemical and enzymatic properties of PLA2 during gestation with a special emphasis on its role for the placental function and development of the fetus. We also critically discuss the possible pathophysiological significance of PLA2 alterations and its possible functional consequences. These alterations are often associated with pregnancy pathologies such as preeclampsia and villitis or pregnancy complications such as obesity and diabetes in the mother as well as preterm onset of labor. © 2016 Society for Reproduction and Fertility.
Find related publications in this database (using NLM MeSH Indexing)
Female -
Humans -
Labor, Obstetric - metabolism
Phospholipases A2 - metabolism
Pregnancy -

© Med Uni Graz • Impressum