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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trieb, M; Horvath, A; Birner-Gruenberger, R; Spindelboeck, W; Stadlbauer, V; Taschler, U; Curcic, S; Stauber, RE; Holzer, M; Pasterk, L; Heinemann, A; Marsche, G.
Liver disease alters high-density lipoprotein composition, metabolism and function.
Biochim Biophys Acta. 2016; 1861(7):630-638
Doi: 10.1016/j.bbalip.2016.04.013
[OPEN ACCESS]
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Marsche Gunther
- Stadlbauer-Köllner Vanessa
- Trieb Markus
- Co-Autor*innen der Med Uni Graz
- Birner-Grünberger Ruth
- Curcic Sanja
- Heinemann Akos
- Holzer Michael
- Horvath Angela
- Spindelböck Walter Johann
- Stauber Rudolf
- Taschler Ulrike
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- Abstract:
- High-density lipoproteins (HDL) are important endogenous inhibitors of inflammatory responses. Functional impairment of HDL might contribute to the excess mortality experienced by patients with liver disease, but the effect of cirrhosis on HDL metabolism and function remain elusive. To get an integrated measure of HDL quantity and quality, we assessed several metrics of HDL function using apolipoprotein (apo) B-depleted sera from patients with compensated cirrhosis, patients with acutely decompensated cirrhosis and healthy controls. We observed that sera of cirrhotic patients showed reduced levels of HDL-cholesterol and profoundly suppressed activities of several enzymes involved in HDL maturation and metabolism. Native gel electrophoresis analyses revealed that cirrhotic serum HDL shifts towards the larger HDL2 subclass. Proteomic assessment of isolated HDL identified several proteins, including apoA-I, apoC-III, apoE, paraoxonase 1 and acute phase serum amyloid A to be significantly altered in cirrhotic patients. With regard to function, these alterations in levels, composition and structure of HDL were strongly associated with metrics of function of apoB-depleted sera, including cholesterol efflux capability, paraoxonase activity, the ability to inhibit monocyte production of cytokines and endothelial regenerative activities. Of particular interest, cholesterol efflux capacity appeared to be strongly associated with liver disease mortality. Our findings may be clinically relevant and improve our ability to monitor cirrhotic patients at high risk. Copyright © 2016 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Apolipoprotein A-I - blood
- Apolipoprotein C-III - blood
- Apolipoproteins B - blood
- Apolipoproteins E - blood
- Aryldialkylphosphatase - blood
- Bilirubin - blood
- Cholesterol, HDL - blood
- Cholesterol, LDL - blood
- Creatinine - blood
- Cross-Sectional Studies -
- Cytokines - biosynthesis
- Cytokines - secretion
- Female -
- Humans -
- Liver - metabolism
- Liver - pathology
- Liver - physiopathology
- Liver Cirrhosis - blood
- Liver Cirrhosis - pathology
- Liver Cirrhosis - physiopathology
- Male -
- Middle Aged -
- Monocytes - metabolism
- Monocytes - pathology
- Serum Albumin - metabolism
- Serum Amyloid A Protein -
- Survival Analysis -
- Triglycerides - blood
- Find related publications in this database (Keywords)
- Liver disease
- HDL-function
- HDL-proteome
- Cholesterol efflux
- Paraoxonase
- LCAT