Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Thonhofer, M; Weber, P; Santana, AG; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG.
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Bioorg Med Chem Lett. 2016; 26(5):1438-1442
Doi: 10.1016/j.bmcl.2016.01.059
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pabst Bettina
- Paschke Eduard
- Schalli Michael
- Tschernutter Marion
- Windischhofer Werner
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- From an easily available partially protected formal derivative of 1-deoxymannojirimycin, by hydroxymethyl chain-branching and further elaboration, lipophilic analogs of the powerful β-d-galactosidase inhibitor 4-epi-isofagomine have become available. New compounds exhibit improved inhibitory activities comparable to benchmark compound NOEV (N-octyl-epi-valienamine) and may serve as leads towards improved and more selective pharmacological chaperones for GM1-gangliosidosis. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Dose-Response Relationship, Drug -
- Enzyme Inhibitors - chemical synthesis
- Enzyme Inhibitors - chemistry
- Enzyme Inhibitors - pharmacology
- Gangliosidosis, GM1 - enzymology
- Gangliosidosis, GM1 - pathology
- Humans -
- Imino Pyranoses - chemical synthesis
- Imino Pyranoses - chemistry
- Imino Pyranoses - pharmacology
- Lysosomes - drug effects
- Lysosomes - enzymology
- Models, Molecular -
- Molecular Structure -
- Structure-Activity Relationship -
- beta-Galactosidase - antagonists & inhibitors
- beta-Galactosidase - metabolism
- Find related publications in this database (Keywords)
- Iminoalditol
- 4-epi-Isofagomine
- Galactosidase inhibitor
- Pharmacological chaperone
- G(M1)-gangliosidosis