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SHR Neuro Cancer Cardio Lipid Metab Microb
Hartmann, P; Seebauer, CT; Mazagova, M; Horvath, A; Wang, L; Llorente, C; Varki, NM; Brandl, K; Ho, SB; Schnabl, B.
Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.
Am J Physiol Gastrointest Liver Physiol. 2016; 310(5):G310-G322
Doi: 10.1152/ajpgi.00094.2015
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- Co-authors Med Uni Graz
- Horvath Angela
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- Abstract:
- Nonalcoholic fatty liver disease (NAFLD) and obesity are characterized by altered gut microbiota, inflammation, and gut barrier dysfunction. Here, we investigated the role of mucin-2 (Muc2) as the major component of the intestinal mucus layer in the development of fatty liver disease and obesity. We studied experimental fatty liver disease and obesity induced by feeding wild-type and Muc2-knockout mice a high-fat diet (HFD) for 16 wk. Muc2 deficiency protected mice from HFD-induced fatty liver disease and obesity. Compared with wild-type mice, after a 16-wk HFD, Muc2-knockout mice exhibited better glucose homeostasis, reduced inflammation, and upregulated expression of genes involved in lipolysis and fatty acid β-oxidation in white adipose tissue. Compared with wild-type mice that were fed the HFD as well, Muc2-knockout mice also displayed higher intestinal and plasma levels of IL-22 and higher intestinal levels of the IL-22 target genes Reg3b and Reg3g. Our findings indicate that absence of the intestinal mucus layer activates the mucosal immune system. Higher IL-22 levels protect mice from diet-induced features of the metabolic syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - metabolism
- Animals -
- Diet, High-Fat -
- Disease Models, Animal -
- Endotoxins - immunology
- Gastrointestinal Microbiome -
- Inflammation - metabolism
- Inflammation - pathology
- Inflammation - prevention & control
- Interleukins - metabolism
- Intestinal Mucosa - immunology
- Intestinal Mucosa - pathology
- Liver - metabolism
- Liver - pathology
- Mice -
- Mice, Knockout -
- Mucin-2 - deficiency
- Mucin-2 - metabolism
- Mucin-2 - pharmacology
- Non-alcoholic Fatty Liver Disease - metabolism
- Non-alcoholic Fatty Liver Disease - pathology
- Non-alcoholic Fatty Liver Disease - prevention & control
- Obesity - metabolism
- Obesity - pathology
- Obesity - prevention & control
- Pancreatitis-Associated Proteins -
- Protective Agents - metabolism
- Protective Agents - pharmacology
- Proteins - metabolism
- Regeneration - immunology
- Find related publications in this database (Keywords)
- microbiome
- metabolic syndrome
- endotoxin
- Reg3