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Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kopecky, C; Genser, B; Drechsler, C; Krane, V; Kaltenecker, CC; Hengstschläger, M; März, W; Wanner, C; Säemann, MD; Weichhart, T.
Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis.
Clin J Am Soc Nephrol. 2015; 10(2):224-231 Doi: 10.2215/CJN.06560714 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: März Winfried
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Abstract:: Impairment of HDL function has been associated with cardiovascular events in patients with kidney failure. The protein composition of HDLs is altered in these patients, presumably compromising the cardioprotective effects of HDLs. This post hoc study assessed the relation of distinct HDL-bound proteins with cardiovascular outcomes in a dialysis population. The concentrations of HDL-associated serum amyloid A (SAA) and surfactant protein B (SP-B) were measured in 1152 patients with type 2 diabetes mellitus on hemodialysis participating in The German Diabetes Dialysis Study who were randomly assigned to double-blind treatment of 20 mg atorvastatin daily or matching placebo. The association of SAA(HDL) and SP-B(HDL) with cardiovascular outcomes was assessed in multivariate regression models adjusted for known clinical risk factors. High concentrations of SAA(HDL) were significantly and positively associated with the risk of cardiac events (hazard ratio per 1 SD higher, 1.09; 95% confidence interval, 1.01 to 1.19). High concentrations of SP-B(HDL) were significantly associated with all-cause mortality (hazard ratio per 1 SD higher, 1.10; 95% confidence interval, 1.02 to 1.19). Adjustment for HDL cholesterol did not affect these associations. In patients with diabetes on hemodialysis, SAA(HDL) and SP-B(HDL) were related to cardiac events and all-cause mortality, respectively, and they were independent of HDL cholesterol. These findings indicate that a remodeling of the HDL proteome was associated with a higher risk for cardiovascular events and mortality in patients with ESRD. Copyright © 2015 by the American Society of Nephrology.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Atorvastatin Calcium -; Biomarkers - blood; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - mortality; Diabetes Mellitus, Type 2 - therapy; Diabetic Nephropathies - blood; Diabetic Nephropathies - diagnosis; Diabetic Nephropathies - etiology; Diabetic Nephropathies - mortality; Diabetic Nephropathies - therapy; Double-Blind Method -; Female -; Female -; Heart Diseases - blood; Heart Diseases - diagnosis; Heart Diseases - etiology; Heart Diseases - mortality; Heart Diseases - therapy; Heptanoic Acids - therapeutic use; Humans -; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - diagnosis; Kidney Failure, Chronic - etiology; Kidney Failure, Chronic - mortality; Kidney Failure, Chronic - therapy; Lipoproteins, HDL - blood; Male -; Middle Aged -; Proportional Hazards Models -; Pulmonary Surfactant-Associated Protein B - blood; Pyrroles - therapeutic use; Renal Dialysis - adverse effects; Renal Dialysis - mortality; Risk Factors -; Serum Amyloid A Protein - metabolism; Time Factors -; Treatment Outcome -