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SHR Neuro Cancer Cardio Lipid Metab Microb
Luschnig, P; Frei, R; Lang-Loidolt, D; Rozsasi, A; Tomazic, PV; Lippe, IT; Schuligoi, R; Heinemann, A.
Altered inhibitory function of the E-type prostanoid receptor 4 in eosinophils and monocytes from aspirin-intolerant patients.
Pharmacology. 2014; 94(5-6):280-286
Doi: 10.1159/000369827
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Luschnig Petra
- Schuligoi Rufina
- Co-authors Med Uni Graz
- Frei-Winterleitner Robert
- Heinemann Akos
- Lang-Loidolt Doris
- Lippe Irmgard Theresia
- Tomazic Peter Valentin
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- Abstract:
- Prostaglandin (PG) E2 has been implicated in the pathogenesis of aspirin-exacerbated respiratory disease (AERD). E-type prostanoid (EP) receptor 4 is known to confer inhibitory signals to eosinophils and monocytes, amongst others. In this study, we investigated whether the responsiveness of eosinophils and monocytes to PGE2 and EP4 receptor activation is altered in AERD patients. While the expression of the EP4 receptor in eosinophils was unaltered in AERD patients, inhibition of eosinophil chemotaxis by PGE2 or the EP4 agonist CAY10598 was less pronounced in AERD patients as compared to healthy control subjects. In monocytes, we found no changes in basal or lipopolysaccharide (LPS)-stimulated PGE2 synthesis, but the response to EP4 receptor activation with respect to inhibition of LPS-induced tumor necrosis factor-α release was reduced in AERD patients, especially in the presence of aspirin (acetylsalicylic acid). Our data point towards a decreased sensitivity of inhibitory EP4 receptor that may play a role in AERD. © 2014 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aspirin - adverse effects
- Aspirin - pharmacology
- Asthma - chemically induced
- Asthma - metabolism
- Calcium - metabolism
- Cell Movement -
- Dinoprostone - metabolism
- Dinoprostone - pharmacology
- Eosinophils - metabolism
- Eosinophils - physiology
- Female -
- Humans -
- Lipopolysaccharides - pharmacology
- Male -
- Middle Aged -
- Monocytes - metabolism
- Pyrrolidinones - pharmacology
- Receptors, Prostaglandin E, EP4 Subtype - agonists
- Receptors, Prostaglandin E, EP4 Subtype - metabolism
- Tetrazoles - pharmacology
- Tumor Necrosis Factor-alpha - metabolism
- Find related publications in this database (Keywords)
- Aspirin-exacerbated respiratory disease
- E-type prostanoid receptor 4
- Eosinophils
- Monocytes
- Prostaglandin E-2
- Tumor necrosis factor-alpha