Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoerl, G; Ledinski, G; Kager, G; Thalhammer, M; Koestenberger, M; Juergens, G; Gary, T; Cvirn, G.
Virtually same oxidizability of LDL but higher Lp(a) levels in arterial compared to venous plasma.
Chem Phys Lipids. 2014; 184(10):38-41
Doi: 10.1016/j.chemphyslip.2014.09.004
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Hörl Gerd
- Co-Autor*innen der Med Uni Graz
- Gary Thomas
- Jürgens Günther
- Kager Gerd
- Koestenberger Martin
- Ledinski Gerhard
- Thalhammer Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Plaque formation is confined to the arterial trunk. We assumed that due to the higher aeration of arterial compared to venous blood, higher levels of the atherogenic agent oxidized LDL might be present in arteries, contributing to plaque formation. We aimed to compare (i) the basal oxidative status of LDL in arterial and venous blood and (ii) the susceptibility of arterial and venous LDL to oxidation. The basal oxidative status of LDL was determined by measuring lipid hydroperoxide (LPO) concentrations, plasma levels of auto-antibodies against oxidized LDL, and by measuring oxidation-specific epitopes on LDL particles. The oxidizability of arterial vs. venous LDL (catalyzed by copper) was estimated by monitoring the time-course of conjugated dienes formation. Interestingly, we found the same basal oxidative status of LDL in arterial and venous plasma. LPO concentrations and levels of auto-antibodies against oxidized LDL were similar in arterial and venous plasma and amounts of oxidation-specific epitopes were similar on the respective LDL particles. Moreover, we found similar susceptibilities of arterial and venous LDL to (copper-mediated) oxidation. Lag-times until the onset of conjugated diene formation were slightly shorter in arterial compared to venous LDL in the presence of 5 μM, but not in the presence of 1 μM CuCl2. Additionally, we found significantly higher levels of the atherogenic lipoprotein(a) in arterial plasma. We conclude that not higher oxidizability of arterial LDL but higher arterial lipoprotein(a) levels might help to explain why sclerosis is confined to the arterial trunk. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antibodies, Monoclonal - immunology
- Arteries - metabolism
- Autoantibodies - blood
- Copper - chemistry
- Epitopes - analysis
- Epitopes - immunology
- Female -
- Humans -
- Immunoassay -
- Lipoproteins, LDL - blood
- Male -
- Middle Aged -
- Veins - metabolism
- Find related publications in this database (Keywords)
- Conjugated diene formation
- Lipid peroxidation
- Lipoprotein(a)
- Oxidation-specific immune epitopes
- Plaque formation