Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Thomas, G; Betters, JL; Lord, CC; Brown, AL; Marshall, S; Ferguson, D; Sawyer, J; Davis, MA; Melchior, JT; Blume, LC; Howlett, AC; Ivanova, PT; Milne, SB; Myers, DS; Mrak, I; Leber, V; Heier, C; Taschler, U; Blankman, JL; Cravatt, BF; Lee, RG; Crooke, RM; Graham, MJ; Zimmermann, R; Brown, HA; Brown, JM.
The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
Cell Rep. 2013; 5(2):508-520 Doi: 10.1016/j.celrep.2013.08.047 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Taschler Ulrike
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Abstract:: The serine hydrolase α/β hydrolase domain 6 (ABHD6) has recently been implicated as a key lipase for the endocannabinoid 2-arachidonylglycerol (2-AG) in the brain. However, the biochemical and physiological function for ABHD6 outside of the central nervous system has not been established. To address this, we utilized targeted antisense oligonucleotides (ASOs) to selectively knock down ABHD6 in peripheral tissues in order to identify in vivo substrates and understand ABHD6's role in energy metabolism. Here, we show that selective knockdown of ABHD6 in metabolic tissues protects mice from high-fat-diet-induced obesity, hepatic steatosis, and systemic insulin resistance. Using combined in vivo lipidomic identification and in vitro enzymology approaches, we show that ABHD6 can hydrolyze several lipid substrates, positioning ABHD6 at the interface of glycerophospholipid metabolism and lipid signal transduction. Collectively, these data suggest that ABHD6 inhibitors may serve as therapeutics for obesity, nonalcoholic fatty liver disease, and type II diabetes. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Amino Acid Sequence -; Animals -; Diet, High-Fat -; Endocannabinoids - metabolism; Fatty Acids - biosynthesis; Humans -; Liver - enzymology Liver - metabolism; Male -; Metabolic Syndrome X - enzymology Metabolic Syndrome X - metabolism Metabolic Syndrome X - pathology; Mice -; Mice, Inbred C57BL -; Molecular Sequence Data -; Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - genetics Monoacylglycerol Lipases - metabolism; Obesity - prevention & control; Oligonucleotides, Antisense - metabolism; Receptor, Cannabinoid, CB1 - metabolism; Sequence Alignment -; Signal Transduction -