Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schreiber, R; Taschler, U; Preiss-Landl, K; Wongsiriroj, N; Zimmermann, R; Lass, A.
Retinyl ester hydrolases and their roles in vitamin A homeostasis.
Biochim Biophys Acta. 2012; 1821(1):113-123 Doi: 10.1016/j.bbalip.2011.05.001 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Schreiber Renate
Co-Autor*innen der Med Uni Graz: Taschler Ulrike
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: In mammals, dietary vitamin A intake is essential for the maintenance of adequate retinoid (vitamin A and metabolites) supply of tissues and organs. Retinoids are taken up from animal or plant sources and subsequently stored in form of hydrophobic, biologically inactive retinyl esters (REs). Accessibility of these REs in the intestine, the circulation, and their mobilization from intracellular lipid droplets depends on the hydrolytic action of RE hydrolases (REHs). In particular, the mobilization of hepatic RE stores requires REHs to maintain steady plasma retinol levels thereby assuring constant vitamin A supply in times of food deprivation or inadequate vitamin A intake. In this review, we focus on the roles of extracellular and intracellular REHs in vitamin A metabolism. Furthermore, we will discuss the tissue-specific function of REHs and highlight major gaps in the understanding of RE catabolism. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism. © 2011 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adipose Tissue - metabolism; Animals -; Biological Transport -; Carboxylic Ester Hydrolases - metabolism; Eye - metabolism; Homeostasis -; Humans -; Lipid Metabolism -; Liver - metabolism; Mice -; Rats -; Skin - metabolism; Vitamin A - metabolism
Find related publications in this database (Keywords): Vitamin A; Retinyl ester hydrolase; Lipid droplet; Mobilization; Neutral lipid; Store