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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kopecky, C; Haidinger, M; Birner-Grünberger, R; Darnhofer, B; Kaltenecker, CC; Marsche, G; Holzer, M; Weichhart, T; Antlanger, M; Kovarik, JJ; Werzowa, J; Hecking, M; Säemann, MD.
Restoration of renal function does not correct impairment of uremic HDL properties.
J Am Soc Nephrol. 2015; 26(3):565-575
Doi: 10.1681/ASN.2013111219
[OPEN ACCESS]
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Birner-Grünberger Ruth
- Darnhofer Barbara
- Holzer Michael
- Marsche Gunther
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- Abstract:
- Cardiovascular disease remains the leading cause of death in renal transplant recipients, but the underlying causative mechanisms for this important problem remain elusive. Recent work has indicated that qualitative alterations of HDL affect its functional and compositional properties in ESRD. Here, we systematically analyzed HDL from stable renal transplant recipients, according to graft function, and from patients with ESRD to determine whether structural and functional properties of HDL remain dysfunctional after renal transplantation. Cholesterol acceptor capacity and antioxidative activity, representing two key cardioprotective mechanisms of HDL, were profoundly suppressed in kidney transplant recipients independent of graft function and were comparable with levels in patients with ESRD. Using a mass spectroscopy approach, we identified specific remodeling of transplant HDL with highly enriched proteins, including α-1 microglobulin/bikunin precursor, pigment epithelium-derived factor, surfactant protein B, and serum amyloid A. In conclusion, this study demonstrates that HDL from kidney recipients is uniquely altered at the molecular and functional levels, indicating a direct pathologic role of HDL that could contribute to the substantial cardiovascular risk in the transplant population. Copyright © 2015 by the American Society of Nephrology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Case-Control Studies -
- Cholesterol, HDL - blood
- Cholesterol, HDL - chemistry
- Female -
- Homeostasis -
- Humans -
- Kidney Failure, Chronic - blood
- Kidney Transplantation -
- Male -
- Middle Aged -
- Proteomics -
- Uremia - blood