Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kleber, ME; Grammer, TB; Kassner, U; Silbernagel, G; März, W.
Dusty punch cards and an eternal enigma: high-density lipoproteins and atherosclerosis.
Drugs. 2014; 74(5):513-520 Doi: 10.1007/s40265-014-0189-5 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
März Winfried
Co-Autor*innen der Med Uni Graz
Silbernagel Günther
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Epidemiological, clinical, and experimental evidence has accumulated during the last decades suggesting that high-density lipoproteins (HDLs) may protect from atherosclerosis and its clinical consequences. However, more than 55 years after the first description of the link between HDL and heart attacks, many facets of the biochemistry, function, and clinical significance of HDL remain enigmatic. This applies particularly to the completely unexpected results that became available from some recent clinical trials of nicotinic acid and of inhibitors of cholesteryl ester transfer protein (CETP). The concept that raising HDL cholesterol by pharmacological means would decrease the risk of vascular disease has therefore been challenged.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Atherosclerosis - blood Atherosclerosis - prevention & control
Cholesterol Ester Transfer Proteins - antagonists & inhibitors
Cholesterol, HDL - blood Cholesterol, HDL - drug effects
Humans -
Myocardial Infarction - blood
Niacin - pharmacology

© Med Uni Graz • Impressum