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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Marsche, G; Heller, R; Fauler, G; Kovacevic, A; Nuszkowski, A; Graier, W; Sattler, W; Malle, E.
2-chlorohexadecanal derived from hypochlorite-modified high-density lipoprotein-associated plasmalogen is a natural inhibitor of endothelial nitric oxide biosynthesis.
ARTERIOSCLER THROMB VASC BIOL. 2004; 24(12): 2302-2306.
Doi: 10.1161/01.ATV.0000148703.43429.25
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- Führende Autor*innen der Med Uni Graz
- Malle Ernst
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Fauler Günter
- Graier Wolfgang
- Sattler Wolfgang
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- Abstract:
- OBJECTIVE: Myeloperoxidase, a heme enzyme that is present and active in human atherosclerotic lesions, provides a source for the generation of proinflammatory chlorinated reactants contributing to endothelial dysfunction. Modification of high-density lipoprotein (HDL) by hypochlorous acid/hypochlorite (HOCl/OCl-) [correction]-generated in vivo by the myeloperoxidase-hydrogen peroxide-chloride system of activated phagocytes-forms a proatherogenic lipoprotein particle that binds to and is internalized by endothelial cells. METHODS AND RESULTS: Here we show that HDL, modified with physiologically relevant HOCl concentrations, attenuates the expression and activity of vasculoprotective endothelial nitric oxide synthase. HOCl-HDL promotes dislocalization of endothelial nitric oxide synthase from the plasma membrane and perinuclear location of human umbilical venous endothelial cells. We could identify 2-chlorohexadecanal as the active component mediating this inhibitory activity. This chlorinated fatty aldehyde is formed during HOCl-mediated oxidative cleavage of HDL-associated plasmalogen. CONCLUSIONS: 2-Chlorohexadecanal, produced by the myeloperoxidase-hydrogen peroxide-chloride system of activated phagocytes may act as a mediator of vascular injury associated with ischemia-reperfusion injury, glomerulosclerosis, and atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aldehydes - metabolism
- Cell Line - metabolism
- Endothelial Cells - enzymology
- Endothelium, Vascular - enzymology
- Enzyme Activation - drug effects
- Humans - drug effects
- Hypochlorous Acid - metabolism
- Lipoproteins, HDL - metabolism
- Nitric Oxide - antagonists and inhibitors
- Nitric Oxide Synthase - antagonists and inhibitors
- Nitric Oxide Synthase Type III - antagonists and inhibitors
- Plasmalogens - metabolism
- Umbilical Veins - cytology
- Find related publications in this database (Keywords)
- myeloperoxidase
- 2-chlorinated fatty aldehyde
- atherosclerosis
- modified lipids
- glomerulosclerosis
- neutrophils