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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Fuchs, C; Claudel, T; Trauner, M.
Bile acid-mediated control of liver triglycerides.
Semin Liver Dis. 2013; 33(4):330-342 Doi: 10.1055/s-0033-1358520
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Führende Autor*innen der Med Uni Graz
Fuchs Claudia
Trauner Michael
Co-Autor*innen der Med Uni Graz
Claudel Thierry
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Abstract:
Bile acids (BAs) are steroidal molecules generated in the liver by cholesterol oxidation. Beside their well-established role in lipid absorption and cholesterol homeostasis, they function as signaling molecules and activate dedicated BA receptors such as the farnesoid X receptor (FXR) and the G-protein coupled receptor TGR5. Through activation of downstream signaling pathways of these key receptors, BAs regulate not only their own synthesis and enterohepatic circulation, but also impact on hepatic lipid, glucose, and energy homeostasis. Therefore, BA-regulated signaling pathways have emerged as attractive targets for understanding the regulation of hepatic triglyceride metabolism in health and disease and treating fatty liver disease and associated metabolic disorders. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Bile Acids and Salts - metabolism Bile Acids and Salts - therapeutic use
Fatty Liver - drug therapy Fatty Liver - metabolism
Humans -
Hypolipidemic Agents - therapeutic use
Liver - drug effects Liver - metabolism
Non-alcoholic Fatty Liver Disease -
Signal Transduction -
Triglycerides - metabolism

Find related publications in this database (Keywords)
farnesoid X receptor
TGR5
FGF15
19
21
nonalcoholic fatty liver disease
nonalcoholic steatohepatitis
glucose
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