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Nina Höller

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SHR Neuro Cancer Cardio Lipid Metab Microb

Sen, A; Marsche, G; Freudenberger, P; Schallert, M; Toeglhofer, AM; Nagl, C; Schmidt, R; Launer, LJ; Schmidt, H.
Association between higher plasma lutein, zeaxanthin, and vitamin C concentrations and longer telomere length: results of the Austrian Stroke Prevention Study.
J Am Geriatr Soc. 2014; 62(2):222-229 Doi: 10.1111/jgs.12644 [OPEN ACCESS]
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Leading authors Med Uni Graz: Schmidt Helena; Sen Abhijit
Co-authors Med Uni Graz: Birkl-Töglhofer Anna Maria; Freudenberger Paul; Marsche Gunther; Schallert Michael; Schmidt Reinhold
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Abstract:: To examine the association between plasma concentrations of antioxidative micronutrients and leukocyte telomere length (LTL) in elderly adults. Cross-sectional cohort study. Austrian Stroke Prevention Study, a population-based cohort study on brain aging. Individuals with a mean age of 66 ± 7 (n = 786; 58% female). Concentrations of vitamin C, lutein, zeaxanthin, β-cryptoxanthin, canthaxanthin, lycopene, α- and γ-tocopherol, α- and β-carotene, and retinol in plasma, advanced oxidation protein products as a measure of oxidative stress in serum, and LTL were measured. Vitamins and carotenoids were measured using high-performance liquid chromatography, advanced oxidation protein products using spectrophotometry, and telomere length using quantitative real-time polymerase chain reaction. Multiple linear regression analyses with adjustment for age and sex demonstrated that higher lutein, zeaxanthin, and vitamin C concentrations were strongly associated with longer telomere length. The associations were independent of body mass index, maximum oxygen uptake, and vascular risk factors and were not mediated by advanced oxidation protein products content. This study provides first evidence that higher lutein, zeaxanthin, and vitamin C concentrations in plasma are associated with longer LTL in normal elderly persons and suggest a protective role of these vitamins in telomere maintenance. © 2014, Copyright the Authors. Journal compilation © 2014, The American Geriatrics Society.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Aging - physiology; Antioxidants - metabolism; Ascorbic Acid - blood; Ascorbic Acid - epidemiology; Chromatography, High Pressure Liquid -; Cross-Sectional Studies -; DNA - analysis; Female -; Follow-Up Studies -; Humans -; Incidence -; Leukocytes - metabolism; Lutein - blood; Male -; Middle Aged -; Oxidative Stress -; Real-Time Polymerase Chain Reaction -; Retrospective Studies -; Spectrophotometry -; Stroke - blood; Telomere Homeostasis - physiology; Xanthophylls - blood
Find related publications in this database (Keywords): telomere length; vitamin C; lutein zeaxanthin; aging; antioxidants; oxidative stress