Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mayer, N; Schweiger, M; Romauch, M; Grabner, GF; Eichmann, TO; Fuchs, E; Ivkovic, J; Heier, C; Mrak, I; Lass, A; Höfler, G; Fledelius, C; Zechner, R; Zimmermann, R; Breinbauer, R.
Development of small-molecule inhibitors targeting adipose triglyceride lipase.
Nat Chem Biol. 2013; 9(12):785-7
Doi: 10.1038/nchembio.1359
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Eichmann Thomas
- Grabner Gernot
- Höfler Gerald
- Romauch Matthias
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue, White - administration & dosage
- Animals - administration & dosage
- Gene Expression Regulation, Enzymologic - administration & dosage
- Inhibitory Concentration 50 - administration & dosage
- Lipase - antagonists & inhibitors, genetics, metabolism
- Mice - administration & dosage
- Mice, Knockout - administration & dosage
- Molecular Structure - administration & dosage
- Phenylurea Compounds - pharmacology