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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

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Dastani, Z; Johnson, T; Kronenberg, F; Nelson, CP; Assimes, TL; März, W; CARDIoGRAM Consortium; ADIPOGen Consortium; Richards, JB.
The shared allelic architecture of adiponectin levels and coronary artery disease.
Atherosclerosis. 2013; 229(1): 145-148. Doi: 10.1016/j.atherosclerosis.2013.03.034 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: März Winfried
Study Group Mitglieder der Med Uni Graz:: Stojakovic Tatjana
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Abstract:: Objective: A large body of epidemiologic data strongly suggests an association between excess adiposity and coronary artery disease (CAD). Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in observational studies. However, these associations cannot clarify whether this relationship is causal or due to a shared set of causal factors or even confounding. Genome-wide association studies have identified common variants that influence adiponectin levels, providing valuable tools to examine the genetic relationship between adiponectin and CAD. Methods: Using 145 genome wide significant SNPs for adiponectin from the ADIPOGen consortium (n = 49,891), we tested whether adiponectin-decreasing alleles influenced risk of CAD in the CARDIoGRAM consortium (n = 85,274). Results: In single-SNP analysis, 5 variants among 145 SNPs were associated with increased risk of CAD after correcting for multiple testing (P < 4.4 x 10(-4)). Using a multi-SNP genotypic risk score to test whether adiponectin levels and CAD have a shared genetic etiology, we found that adiponectin-decreasing alleles increased risk of CAD (P = 5.4 x 10(-7)). Conclusion: These findings demonstrate that adiponectin levels and CAD have a shared allelic architecture and provide rationale to undertake a Mendelian randomization studies to understand if this relationship is causal. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adiponectin - genetics; Adiposity - genetics; Alleles -; Atherosclerosis - epidemiology; Coronary Artery Disease - epidemiology; Databases, Genetic -; Genetic Predisposition to Disease - epidemiology; Genome-Wide Association Study -; Genotype -; Humans -; Male -; Polymorphism, Single Nucleotide -; Prevalence -; Risk Factors -
Find related publications in this database (Keywords): Adiponectin; Coronary artery disease; Atherosclerosis; Gene; Association; SNP