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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, M; Wolf, P; Inzinger, M; Trieb, M; Curcic, S; Pasterk, L; Weger, W; Heinemann, A; Marsche, G.
Anti-psoriatic therapy recovers high-density lipoprotein composition and function.
J Invest Dermatol. 2014; 134(3):635-642
Doi: 10.1038/jid.2013.359
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- Führende Autor*innen der Med Uni Graz
- Holzer Michael
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Curcic Sanja
- Heinemann Akos
- Inzinger Martin
- Pasterk Lisa
- Trieb Markus
- Weger Wolfgang
- Wolf Peter
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- Abstract:
- Psoriasis is a chronic inflammatory disorder associated with increased cardiovascular mortality. Psoriasis affects high-density lipoprotein (HDL) composition, generating dysfunctional HDL particles. However, data regarding the impact of anti-psoriatic therapy on HDL composition and function are not available. HDL was isolated from 15 psoriatic patients at baseline and after effective topical and/or systemic anti-psoriatic therapy and from 15 age- and sex-matched healthy controls. HDL from psoriatic patients showed a significantly impaired capability to mobilize cholesterol from macrophages (6.4 vs. 8.0% [(3)H]cholesterol efflux, P<0.001), low paraoxonase (217 vs. 350 μM(-1) minute(-1) mg(-1) protein, P=0.011) and increased Lp-PLA2 activities (19.9 vs. 12.1 nM(-1) minute(-1) mg(-1) protein, P=0.028). Of particular interest, the anti-psoriatic therapy significantly improved serum lecithin-cholesterol acyltransferase activity and decreased total serum lipolytic activity but did not affect serum levels of HDL-cholesterol. Most importantly, these changes were associated with a significantly improved HDL-cholesterol efflux capability. Our results provide evidence that effective anti-psoriatic therapy recovers HDL composition and function, independent of serum HDL-cholesterol levels, and support to the emerging concept that HDL function may be a better marker of cardiovascular risk than HDL-cholesterol levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Topical -
- Adult -
- Aged -
- Antigens, Human Platelet - metabolism
- Aryldialkylphosphatase - metabolism
- Cardiovascular Diseases - metabolism
- Cardiovascular Diseases - mortality
- Cholesterol - pharmacokinetics
- Female -
- Humans -
- Lipolysis - drug effects
- Lipolysis - physiology
- Lipoproteins, HDL - blood
- Macrophages - metabolism
- Male -
- Middle Aged -
- PUVA Therapy -
- Phosphatidylcholine-Sterol O-Acyltransferase - metabolism
- Psoriasis - drug therapy
- Psoriasis - immunology
- Psoriasis - metabolism
- Risk Factors -
- Tritium -