Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Doddapattar, P; Radović, B; Patankar, JV; Obrowsky, S; Jandl, K; Nusshold, C; Kolb, D; Vujić, N; Doshi, L; Chandak, PG; Goeritzer, M; Ahammer, H; Hoefler, G; Sattler, W; Kratky, D.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Mol Nutr Food Res. 2013; 57(10):1718-1728
Doi: 10.1002/mnfr.201200794
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Doddapattar Prakash
- Kratky Dagmar
- Radovic Branislav
- Co-Autor*innen der Med Uni Graz
- Ahammer Helmut
- Chandak Prakash Gopal Das
- Doshi Lalitkumar Subhash
- Göritzer Madeleine
- Höfler Gerald
- Jandl Katharina
- Kolb Dagmar
- Nusshold Christoph
- Obrowsky Sascha
- Patankar Jay Vasant
- Sattler Wolfgang
- Vujic Nemanja
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Xanthohumol (XN), a prenylated antioxidative and anti-inflammatory chalcone from hops, exhibits positive effects on lipid and glucose metabolism. Based on its favorable biological properties, we investigated whether XN attenuates atherosclerosis in western-type diet-fed apolipoprotein-E-deficient (ApoE⁻/⁻) mice. XN supplementation markedly reduced plasma cholesterol concentrations, decreased atherosclerotic lesion area, and attenuated plasma concentrations of the proinflammatory cytokine monocyte chemoattractant protein 1. Decreased hepatic triglyceride and cholesterol content, activation of AMP-activated protein kinase, phosphorylation and inactivation of acetyl-CoA carboxylase, and reduced expression levels of mature sterol regulatory element-binding protein (SREBP)-2 and SREBP-1c mRNA indicate reduced lipogenesis in the liver of XN-fed ApoE⁻/⁻ mice. Concomitant induction of hepatic mRNA expression of carnitine palmitoyltransferase-1a in ApoE⁻/⁻ mice-administered XN suggests increased fatty acid beta-oxidation. Fecal cholesterol concentrations were also markedly increased in XN-fed ApoE⁻/⁻ mice compared with mice fed western-type diet alone. The atheroprotective effects of XN might be attributed to combined beneficial effects on plasma cholesterol and monocyte chemoattractant protein 1 concentrations and hepatic lipid metabolism via activation of AMP-activated protein kinase. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Find related publications in this database (using NLM MeSH Indexing)
- AMP-Activated Protein Kinases - metabolism
- Acetyl-CoA Carboxylase - antagonists & inhibitors
- Animals -
- Apolipoproteins E - blood
- Carnitine O-Palmitoyltransferase - genetics
- Chemokine CCL2 - blood
- Cholesterol - blood
- Fatty Liver - drug therapy
- Female -
- Flavonoids - pharmacology
- Hypercholesterolemia - drug therapy
- Lipid Metabolism - drug effects
- Lipogenesis - drug effects
- Liver - drug effects
- Mice -
- Phosphorylation -
- Plaque, Atherosclerotic - drug therapy
- Propiophenones - pharmacology
- RNA, Messenger - genetics
- Sterol Regulatory Element Binding Protein 1 - genetics
- Sterol Regulatory Element Binding Protein 2 - genetics
- Triglycerides - blood
- Find related publications in this database (Keywords)
- AMPK signaling
- Atherosclerosis
- Inflammation
- Lipid metabolism
- Xanthohumol