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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Konya, V; Marsche, G; Schuligoi, R; Heinemann, A.
E-type prostanoid receptor 4 (EP4) in disease and therapy.
Pharmacol Ther. 2013; 138(3):485-502
Doi: 10.1016/j.pharmthera.2013.03.006
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- Führende Autor*innen der Med Uni Graz
- Heinemann Akos
- Konya Viktoria
- Co-Autor*innen der Med Uni Graz
- Marsche Gunther
- Schuligoi Rufina
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- Abstract:
- The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse strains with genetic ablation of each EP receptor subtype and the development of selective EP agonists and antagonists have tremendously advanced our understanding of PGE2 as a physiologically and clinically relevant mediator. Moreover, studies using disease models revealed numerous conditions in which distinct EP receptors might be exploited therapeutically. In this context, the EP4 receptor is currently emerging as most versatile and promising among PGE2 receptors. Anti-inflammatory, anti-thrombotic and vasoprotective effects have been proposed for the EP4 receptor, along with its recently described unfavorable tumor-promoting and pro-angiogenic roles. A possible explanation for the diverse biological functions of EP4 might be the multiple signaling pathways switched on upon EP4 activation. The present review attempts to summarize the EP4 receptor-triggered signaling modules and the possible therapeutic applications of EP4-selective agonists and antagonists.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bone Diseases - metabolism
- Cardiovascular Diseases - metabolism
- Dinoprostone - metabolism
- Gastrointestinal Diseases - metabolism
- Humans -
- Immunologic Factors - metabolism
- Kidney Diseases - metabolism
- Lung Diseases - metabolism
- Neoplasms - metabolism
- Receptors, Prostaglandin E, EP4 Subtype - agonists Receptors, Prostaglandin E, EP4 Subtype - antagonists & inhibitors Receptors, Prostaglandin E, EP4 Subtype - metabolism
- Find related publications in this database (Keywords)
- Prostaglandins
- Inflammation
- Vascular disease
- Cancerogenesis
- Renal function
- Osteoporosis