Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

van Poppel, MN; Zeck, W; Ulrich, D; Schest, EC; Hirschmugl, B; Lang, U; Wadsack, C; Desoye, G.
Cord blood chemerin: differential effects of gestational diabetes mellitus and maternal obesity.
Clin Endocrinol (Oxf). 2014; 80(1):65-72 Doi: 10.1111/cen.12140
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Wadsack Christian
Co-Autor*innen der Med Uni Graz: Desoye Gernot; Gold ehem Ulrich Daniela; Hirschmugl Birgit; Lang Uwe; Schest Eva-Christina; Zeck Willibald
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that foetal chemerin would be elevated in gestational diabetes mellitus (GDM) and correlate with foetal and maternal adiposity. Observational, longitudinal study. Foetal chemerin was measured separately in arterial and venous cord blood of 30 infants born to mothers with (n = 15) and without GDM (n = 15), in their mothers in early third trimester and at delivery and in amniotic fluid (week 32) of women with GDM. Expression of chemerin and its receptor in human foetal tissues commercially available and in placental cells was measured by quantitative PCR. Associations between foetal and maternal anthropometric and metabolic variables were assessed in multivariate regression models. In GDM, foetal arterial but not venous cord blood chemerin levels were elevated by about 60% (P < 0·05). Venous cord blood chemerin was higher in infants of obese women (P < 0·01). In multivariate analyses, neither amniotic fluid nor cord blood chemerin levels correlated with birth weight or ponderal index. Both arterial and venous chemerin levels were related to maternal chemerin at birth, and arterial chemerin was associated with GDM status in addition. Maternal levels were unaltered in GDM, but higher in maternal obesity. Foetal liver produces fourfold more chemerin mRNA than other foetal tissues, whereas its receptor prevails in spleen. Based on multivariate analyses, foetal growth appears unrelated to foetal chemerin. Maternal obesity and GDM have differential effects on foetal chemerin levels. Site of major production (liver) and action (spleen) differ in human foetal tissues. © 2013 John Wiley & Sons Ltd.
Find related publications in this database (using NLM MeSH Indexing): Adiposity - physiology; Adult -; Amniocentesis -; Chemokines - blood; Diabetes, Gestational - metabolism; Female -; Fetal Blood - metabolism; Fetus - metabolism; Glucose Tolerance Test -; Humans -; Intercellular Signaling Peptides and Proteins -; Longitudinal Studies -; Multivariate Analysis -; Obesity - blood; Pregnancy -; Real-Time Polymerase Chain Reaction -; Young Adult -