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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Marsche, G; Saemann, MD; Heinemann, A; Holzer, M.
Inflammation alters HDL composition and function: Implications for HDL-raising therapies.
Pharmacol Ther. 2013; 137(3):341-351
Doi: 10.1016/j.pharmthera.2012.12.001
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
- Holzer Michael
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- Abstract:
- There is clear epidemiological evidence that plasma levels of high-density lipoprotein (HDL)-cholesterol are inverse and independent predictors of cardiovascular disease risk, fueling interest in novel therapies capable of raising HDL-cholesterol. However, the relevance of HDL-cholesterol as a surrogate marker for HDL-related risk has been questioned. Latest failures of HDL-cholesterol raising drugs and a recent study that showed no causal association between risk for myocardial infarction and genetically raised plasma HDL-cholesterol indicate that steady-state HDL-cholesterol concentrations may provide limited information regarding the potential antiatherogenic functions of HDL. There is accumulating evidence that HDL composition determines its functional properties, rather than the levels of circulating HDL-cholesterol. Therefore, assessing HDL composition and function might provide more relevant information than steady-state HDL-cholesterol levels. Recent mass spectrometric analyses revealed that protein composition of HDL is complex, expanding our understanding of the functions and structures of lipoproteins. Significant alterations were identified in the composition and function of circulating HDL of patients with high cardiovascular risk, as well as in HDL isolated from atherosclerotic tissue. These novel insights may help to develop therapies that target the functionality of HDL and further enable the identification of patients at increased cardiovascular risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control
- Humans -
- Inflammation - metabolism
- Lipoproteins, HDL - metabolism
- Protein Processing, Post-Translational -
- Find related publications in this database (Keywords)
- High-density lipoprotein
- Dysfunctional HDL
- HDL proteome
- Phospholipids
- Cholesterol efflux