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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Radovic, B; Aflaki, E; Kratky, D.
Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis.
Biol Chem. 2012; 393(9):1005-1011
Doi: 10.1515/hsz-2012-0192
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- Führende Autor*innen der Med Uni Graz
- Aflaki Elma
- Radovic Branislav
- Co-Autor*innen der Med Uni Graz
- Kratky Dagmar
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- Abstract:
- Consistent with its central importance in lipid and energy homeostasis, lipolysis occurs in essentially all tissues and cell types, including macrophages. The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes or as energy substrate in mitochondria. This review summarizes the current knowledge concerning the consequences of ATGL deficiency in macrophages with particular emphasis on macrophage (dys)-function, apoptosis, and atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - enzymology
- Animals -
- Atherosclerosis - enzymology
- Disease Models, Animal -
- Humans -
- Inflammation - enzymology
- Lipase - immunology
- Lipolysis -
- Mice -
- Triglycerides - immunology
- Find related publications in this database (Keywords)
- apoptosis
- lipolysis
- lipotoxicity
- macrophages
- mouse model
- triacylglycerol mobilization