Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Scholler, M; Wadsack, C; Metso, J; Chirackal Manavalan, AP; Sreckovic, I; Schweinzer, C; Hiden, U; Jauhiainen, M; Desoye, G; Panzenboeck, U.
Phospholipid Transfer Protein Is Differentially Expressed in Human Arterial and Venous Placental Endothelial Cells and Enhances Cholesterol Efflux to Fetal HDL.
J Clin Endocrinol Metab. 2012; 97(7):2466-2474 Doi: 10.1210/jc.2011-2969 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: Panzenboeck Ute; Scholler Monika
Co-Autor*innen der Med Uni Graz: Chirackal Manavalan Anil Paul; Desoye Gernot; Hiden Ursula; Schweinzer Cornelia Katrin; Sreckovic Ivana; Wadsack Christian
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Abstract:: Context: Phospholipid (PL) transfer protein (PLTP) plays a crucial role in high-density lipoprotein (HDL) metabolism. In the fetal circulation, HDL particles are the main cholesterol carriers and are involved in maternal-fetal cholesterol transfer across human placental endothelial cells (HPEC). Objective: The aim was to investigate local function(s) of PLTP at the fetoplacental endothelium. Because HPEC display morphological and functional diversity when isolated from arteries or veins, we hypothesized that PLTP activity may differ between arterial and venous HPEC. Design: We determined PLTP mRNA and activity levels from isolated HPEC and investigated PLTP-mediated remodeling of fetal HDL particles and their capacity in mediating cholesterol efflux from HPEC. Results: Incubation of fetal HDL with active human plasma PLTP resulted in increased particle size (12.6 vs. 13.2 nm, P < 0.05), with a concomitant increase (3.5-fold) in pre-beta-mobile HDL particles. Arterial HPEC showed higher Pltp expression levels and secreted PL transfer activity (1.8-fold, P < 0.001) than venous HPEC. In contrast to adult HDL3, [H-3] cholesterol efflux to fetal HDL was 21% higher (P < 0.05) from arterial than from venous HPEC. PLTP-facilitated particle conversion increased the cholesterol efflux capacity of fetal HDL to similar extents (55 and 48%, P < 0.001) from arterial and venous HPEC, respectively. Conclusion: PLTP mediates PL transfer and participates in reverse cholesterol transport pathways at the fetoplacental barrier. Enhanced cellular cholesterol efflux from HPEC to fetal HDL remodeled by PLTP supports the idea of a local atheroprotective role of PLTP in the placental vasculature. (J Clin Endocrinol Metab 97: 2466-2474, 2012)
Find related publications in this database (using NLM MeSH Indexing): Adult -; Biological Transport - genetics Biological Transport - physiology; Cells, Cultured -; Cholesterol - blood Cholesterol - metabolism; Cholesterol, HDL - blood; Endothelial Cells - metabolism; Female -; Fetus - blood supply Fetus - metabolism; Gene Expression Regulation -; Humans -; Phospholipid Transfer Proteins - genetics Phospholipid Transfer Proteins - metabolism Phospholipid Transfer Proteins - physiology; Placenta - blood supply Placenta - metabolism; Placental Circulation - genetics Placental Circulation - physiology; Pregnancy -; Tissue Distribution -; Umbilical Veins - metabolism; Up-Regulation - genetics; Uterine Artery - metabolism