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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhang, Y; Lei, T; Huang, JF; Wang, SB; Zhou, LL; Yang, ZQ; Chen, XD.
The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes.
Mol Cell Endocrinol. 2011; 342(1-2): 41-47.
Doi: 10.1016/j.mce.2011.05.003
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Huang Jianfeng
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- Abstract:
- Recently fibroblast growth factor 21 (FGF21) has been identified as a potent regulator in glucose and lipid homeostasis. Here, we firstly investigated the metabolic role of FGF21 in human liver-derived HepG2 cells, and suggested that overexpression of FGF21 suppressed triglyceride accumulation by inhibiting the transcription of the gene necessary for de novo lipogenesis. The potential mechanism of FGF21 regulating lipogenesis was also explored, which revealed that FGF21 repressed the transcription of sterol regulatory element binding protein 1c (SREBP1c), an essential transcription factor promoting expression of lipogenesis-related genes. Overexpression of FGF21 ameliorated the up-regulation of SREBP1c and fatty acid synthase (FAS) in HepG2 cells elicited by FFAs treatment. Moreover, FGF21 could inhibit the transcriptional levels of the key genes involved in processing and nuclear translocation of SREBP1c, and decrease the protein amount of mature SREBP1c. Unexpectedly, overexpression of SREBP1c in HepG2 cells could also inhibit the endogenous FGF21 transcription. Further experiments demonstrated that SREBP1c could significantly attenuate the promoter activity of FGF21. In conclusion, our data identifies a clear link between FGF21 and SREBP1c during lipogenesis in hepatocyte in culture.
- Find related publications in this database (using NLM MeSH Indexing)
- Active Transport, Cell Nucleus -
- Animals -
- Cell Line -
- Fatty Acid Synthetase Complex - genetics Fatty Acid Synthetase Complex - metabolism
- Fatty Acids - biosynthesis
- Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism
- Gene Expression Regulation -
- Hepatocytes - metabolism
- Humans -
- Lipogenesis - genetics
- Liver - metabolism
- Mice -
- Promoter Regions, Genetic - genetics
- RNA, Messenger - genetics RNA, Messenger - metabolism
- Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism
- Transcription, Genetic -
- Triglycerides - genetics Triglycerides - metabolism
- Find related publications in this database (Keywords)
- FGF21
- Lipogenesis
- SREBP1c
- Promoter
- Hepatocyte