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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Bechmann, LP; Hannivoort, RA; Gerken, G; Hotamisligil, GS; Trauner, M; Canbay, A.
The interaction of hepatic lipid and glucose metabolism in liver diseases.
J Hepatol. 2012; 56(4):952-964 Doi: 10.1016/j.jhep.2011.08.025 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Trauner Michael
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Abstract:
It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and cholesterol metabolism. However, over the last decades, a variety of pathological conditions highlighted the importance of metabolic functions within the diseased liver. As observed in Western societies, an increase in the prevalence of obesity and the metabolic syndrome promotes pathophysiological changes that cause non-alcoholic fatty liver disease (NAFLD). NAFLD increases the susceptibility of the liver to acute liver injury and may lead to cirrhosis and hepatocellular cancer. Alterations in insulin response, β-oxidation, lipid storage and transport, autophagy and an imbalance in chemokines and nuclear receptor signaling are held accountable for these changes. Furthermore, recent studies revealed a role for lipid accumulation in inflammation and ER stress in the clinical context of liver regeneration and hepatic carcinogenesis. This review focuses on novel findings related to nuclear receptor signaling - including the vitamin D receptor and the liver receptor homolog 1 - in hepatic lipid and glucose uptake, storage and metabolism in the clinical context of NAFLD, liver regeneration, and cancer.
Find related publications in this database (using NLM MeSH Indexing)
Fatty Liver - metabolism
Glucose - metabolism
Humans -
Lipid Metabolism - physiology
Liver Neoplasms - metabolism
Liver Regeneration - physiology
Receptors, Calcitriol - metabolism
Receptors, Cytoplasmic and Nuclear - metabolism

Find related publications in this database (Keywords)
NAFLD
Fatty acid transporters
HCC
Liver regeneration
Nuclear receptors
ER stress
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