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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, M; Birner-Gruenberger, R; Stojakovic, T; El-Gamal, D; Binder, V; Wadsack, C; Heinemann, A; Marsche, G.
Uremia Alters HDL Composition and Function.
J Am Soc Nephrol. 2011; 22(9):1631-1641
Doi: 10.1681/ASN.2010111144
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- Führende Autor*innen der Med Uni Graz
- Holzer Michael
- Marsche Gunther
- Co-Autor*innen der Med Uni Graz
- Binder Veronika
- Birner-Grünberger Ruth
- El-Gamal Dalia
- Heinemann Akos
- Stojakovic Tatjana
- Wadsack Christian
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- Abstract:
- Functional impairment of HDL may contribute to the excess cardiovascular mortality experienced by patients with renal disease, but the effect of advanced renal disease on the composition and function of HDL is not well understood. Here, we used mass spectrometry and biochemical analyses to study alterations in the proteome and lipid composition of HDL isolated from patients on maintenance hemodialysis. We identified a significant increase in the amount of acute phase protein serum amyloid A1, albumin, lipoprotein-associated phospholipase A2, and apoC-III composing uremic HDL. Furthermore, uremic HDL contained reduced phospholipid and increased triglyceride and lysophospholipid. With regard to function, these changes impaired the ability of uremic HDL to promote cholesterol efflux from macrophages. In summary, the altered composition of HDL in renal disease seems to inhibit its cardioprotective properties. Assessing HDL composition and function in renal disease may help identify patients at increased risk for cardiovascular disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Albumins - metabolism
- Apolipoprotein C-III - blood
- Case-Control Studies -
- Cell Line -
- Cholesterol - metabolism
- Chromatography, Liquid -
- Humans -
- Kidney Failure, Chronic - blood
- Lipoproteins, HDL - blood
- Male -
- Middle Aged -
- Phospholipids - metabolism
- Proteome -
- Renal Dialysis -
- Serum Amyloid A Protein - metabolism
- Tandem Mass Spectrometry -
- Triglycerides - analysis
- Uremia - blood