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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tancevski, I; Eller, P; Patsch, JR; Ritsch, A.
The resurgence of thyromimetics as lipid-modifying agents.
Curr Opin Investig Drugs. 2009; 10(9):912-918
[OPEN ACCESS]
Web of Science
PubMed
- Co-Autor*innen der Med Uni Graz
- Eller Philipp
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- Abstract:
- The aggressive reduction of LDL-cholesterol levels by treatment with statins is a key component of preventive cardiovascular care; however, additional therapies to prevent atherosclerosis and the associated clinical sequelae are still needed. Thyromimetic compounds selective for the liver or for the thyroid hormone receptor isoform beta1 constitute a novel approach for the treatment of dyslipidemia. In preclinical studies, selective thyromimetics significantly reduced plasma cholesterol levels and provided protection from atherosclerosis by upregulating the hepatic LDL receptor and promoting reverse cholesterol transport. Importantly, data from ongoing clinical trials have provided the first evidence that selective thyromimetics may also reduce the levels of plasma cholesterol in humans.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetic Acids - chemistry Acetic Acids - pharmacology
- Anilides - chemistry Anilides - pharmacology
- Animals -
- Anticholesteremic Agents - therapeutic use
- Arteriosclerosis - drug therapy Arteriosclerosis - prevention and control
- Atherosclerosis - prevention and control
- Biological Transport -
- Biomimetics -
- Cholesterol, LDL - blood Cholesterol, LDL - metabolism
- Clinical Trials as Topic -
- Dyslipidemias - drug therapy
- Humans -
- Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
- Hypolipidemic Agents - therapeutic use
- Lipid Metabolism -
- Malonates - pharmacology
- Molecular Structure -
- Phenols - chemistry Phenols - pharmacology
- Phenyl Ethers - pharmacology
- Phenylacetates - pharmacology
- Phosphonic Acids - chemistry Phosphonic Acids - pharmacology
- Propionic Acids - pharmacology
- Pyridazines - pharmacology
- Receptors, LDL - metabolism
- Thyroid Gland - drug effects
- Thyroid Hormones - metabolism
- Find related publications in this database (Keywords)
- Atherosclerosis
- LDL receptor
- reverse cholesterol transport
- selective thyromimetic