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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Desoye, G; Gauster, M; Wadsack, C.
Placental transport in pregnancy pathologies.
Am J Clin Nutr. 2011; 94(6 Suppl):1896S-11902 Doi: 10.3945/ajcn.110.000851 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Desoye Gernot
Co-Autor*innen der Med Uni Graz
Gauster Martin
Wadsack Christian
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Abstract:
The placenta is positioned between the maternal and fetal circulation and hence plays a key role in transporting maternal nutrients to the developing fetus. Fetal growth changes in the 2 most frequent pregnancy pathologies, gestational diabetes mellitus and fetal growth restriction, are predominantly characterized by an exaggerated and restricted fat accretion, respectively. Glucose, by its regulating effect on fetal insulin concentrations, and lipids have been strongly implicated in fetal fat deposition. Transplacental glucose flux is highly efficient and limited only by nutrient availability (flow-limited)--ie, driven by the maternal-fetal glucose concentration gradient and blood flow, with little, if any, effect of placental morphology, glucose consumption, and transporter expression. This explains why, despite changes in these determinants in both pathologies, transplacental glucose flux is unaltered.
Find related publications in this database (using NLM MeSH Indexing)
Blood Glucose - analysis
Diabetes, Gestational - pathology
Female -
Fetal Development - drug effects
Fetal Growth Retardation - pathology
Fetus - metabolism Fetus - physiopathology
Humans -
Insulin - metabolism
Lipase - genetics Lipase - metabolism
Placenta - blood supply
Placental Circulation - drug effects
Pregnancy -
Pregnancy Complications - pathology
Receptors, Lipoprotein - metabolism

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