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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vetter, A; Reinisch, A; Strunk, D; Kremser, C; Hahn, HW; Huck, CW; Ostermann, T; Leithner, K; Bernkop-Schnürch, A.
Thiolated polyacrylic acid-modified iron oxide nanoparticles for in vitro labeling and MRI of stem cells.
J Drug Target. 2011; 19(7):562-572
Doi: 10.3109/1061186X.2010.542243
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Reinisch Andreas
- Strunk Dirk
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- Abstract:
- The purpose of this study was to develop and characterize new surface-modified iron oxide nanoparticles demonstrating the efficiency to be internalized by human endothelial progenitor cells (EPCs) from umbilical cord blood. Iron oxide nanoparticles were coated with polyacrylic acid-cysteine (PAA-Cys) by either in situ precipitation or postsynthesis. The nanoparticles were characterized by X-ray powder diffraction. EPCs were labeled with PAA-Cys-modified iron oxide nanoparticles or with uncoated nanoparticles. The relaxivity of uncoated and coated iron oxide nanoparticles as well as EPCs labeled with PAA-Cys-modified iron oxide were determined. Addition of PAA-Cys increased the particle size from 10.4 to 144 and 197 nm, respectively. The X-ray powder diffraction pattern revealed that the particles consist of Fe(3)O(4) with a spinal structure. Postsynthesis coated particles showed a cellular uptake of 85% and 15.26 pg iron/cell. For both types of particles the relaxivity ratio was at least 2-fold higher than that of the gold standard Resovist(®). The PAA-Cys coated iron oxide nanoparticles are a promising tool for labeling living cells such as stem cells for diagnostic and therapeutic application in cell-based therapies due to their high relaxivities and their easy uptake by cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Acrylic Resins - chemistry
- Cells, Cultured -
- Ferric Compounds - chemistry
- Humans -
- Magnetic Resonance Imaging -
- Metal Nanoparticles -
- Powder Diffraction -
- Spectroscopy, Fourier Transform Infrared -
- Sulfhydryl Compounds - chemistry
- Find related publications in this database (Keywords)
- Stem cells
- nanoparticles
- iron oxide
- thiomers
- relaxivity