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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Patankar, JV; Chandak, PG; Obrowsky, S; Pfeifer, T; Diwoky, C; Uellen, A; Sattler, W; Stollberger, R; Hoefler, G; Heinemann, A; Battle, M; Duncan, S; Kratky, D; Levak-Frank, S.
Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.
Am J Physiol Endocrinol Metab. 2011; 300(3): E478-E488.
Doi: 10.1152/ajpendo.00457.2010
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- Führende Autor*innen der Med Uni Graz
- Levak Sanja
- Patankar Jay Vasant
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
- Höfler Gerald
- Kratky Dagmar
- Obrowsky Sascha
- Sattler Wolfgang
- Üllen Andreas
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- Abstract:
- Transcriptional regulation of small intestinal gene expression controls plasma total cholesterol (TC) and triglyceride (TG) levels, which are major determinants of metabolic diseases. GATA4, a zinc finger domain transcription factor, is critical for jejunal identity, and intestinal GATA4 deficiency leads to a jejunoileal transition. Although intestinal GATA4 ablation is known to misregulate jejunal gene expression, its pathophysiological impact on various components of metabolic syndrome remains unknown. Here, we used intestine-specific GATA4 knockout (GATA4iKO) mice to dissect the contribution of GATA4 on obesity development. We challenged adult GATA4iKO mice and control littermates with a Western-type diet (WTD) for 20 wk. Our findings show that WTD-fed GATA4iKO mice are resistant to diet-induced obesity. Accordingly, plasma TG and TC levels are markedly decreased. Intestinal lipid absorption in GATA4iKO mice was strongly reduced, whereas luminal lipolysis was unaffected. GATA4iKO mice displayed a greater glucagon-like peptide-1 (GLP-1) release on normal chow and even after long-term challenge with WTD remained glucose sensitive. In summary, our findings show that the absence of intestinal GATA4 has a beneficial effect on decreasing intestinal lipid absorption causing resistance to hyperlipidemia and obesity. In addition, we show that increased GLP-1 release in GATA4iKO mice decreases the risk for development of insulin resistance.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - anatomy and histology
- Animals -
- Diet -
- Dietary Fats - pharmacokinetics
- Enzyme-Linked Immunosorbent Assay -
- Feces - chemistry
- GATA4 Transcription Factor - genetics
- Gastric Emptying - physiology
- Glucagon-Like Peptide 1 - physiology
- Glucose Tolerance Test -
- Hyperlipidemias - genetics
- Insulin Resistance - genetics
- Intestinal Absorption - genetics
- Intestines - metabolism
- Lipolysis - physiology
- Magnetic Resonance Imaging -
- Mice -
- Mice, Knockout -
- Obesity - genetics
- RNA - biosynthesis
- Reverse Transcriptase Polymerase Chain Reaction -
- Tissue Distribution -
- Find related publications in this database (Keywords)
- ileal interposition
- triglyceride absorption
- obesity
- glucagon-like peptide-1
- CD36