Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zorn-Pauly, K; Schaffer, P; Pelzmann, B; Bernhart, E; Wei, G; Lang, P; Ledinski, G; Greilberger, J; Koidl, B; Jürgens, G.
Oxidized LDL induces ventricular myocyte damage and abnormal electrical activity--role of lipid hydroperoxides.
Cardiovasc Res. 2005; 66(1):74-83
Doi: 10.1016/j.cardiores.2004.12.009
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Schaffer Peter
- Zorn-Pauly Klaus
- Co-Autor*innen der Med Uni Graz
- Bernhart Eva Maria
- Greilberger Joachim
- Jürgens Günther
- Koidl Bernd
- Lang Petra
- Ledinski Gerhard
- Pelzmann Brigitte
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- It was our aim to investigate effects of human LDL, copper-, or AAPH-oxidized over different periods of time to different degrees (ox-LDL), on viability and electrophysiological parameters of isolated ventricular myocytes of guinea pigs. Guinea pig ventricular myocytes were incubated with ox-LDL or native LDL (at 0.5 mg/ml) for 12 h, and afterwards myocyte damage, action potentials, and transmembrane ion currents were studied (at 37 degrees C). Ox-LDL was found to induce severe myocyte damage, whereas native LDL had no effect. Myocyte damage was dependent on the content of total lipid hydroperoxides in both copper-oxidized and AAPH-oxidized LDL. Incubation with ox-LDL led to intense contractile and electrophysiological effects including prolongation of action potential duration, depolarization of resting membrane potential, spontaneous activity, generation of afterdepolarizations, and modification of transmembrane ion currents (e.g. inward rectifier, calcium, and background currents). Ox-LDL induced cell damage and irregular electrical activity in ventricular myocytes. These effects were dependent on the lipid hydroperoxide content of ox-LDL and were similar to oxidative stress (OS) induced by various OS-generating systems. The observed effects may play a role for functional cardiac abnormalities in patients with increased ox-LDL levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Action Potentials - drug effects
- Adult -
- Amidines - metabolism
- Animals -
- Calcium Channels - drug effects
- Cell Culture Techniques -
- Cell Survival -
- Copper - metabolism
- Guinea Pigs -
- Heart Ventricles -
- Humans -
- Ion Channels - drug effects
- Lipid Peroxides - metabolism
- Lipoproteins, LDL - pharmacology
- Male -
- Membrane Potentials - drug effects
- Myocytes, Cardiac - metabolism
- Myocytes, Cardiac - pathology
- Oxidation-Reduction -
- Potassium Channels, Inwardly Rectifying - drug effects
- Find related publications in this database (Keywords)
- lipoproteins
- oxygen radicals
- repolarization
- membrane currents ion channels