Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Prenn, C; Heinemann, A; Schuligoi, R; Peskar, BA.
CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine.
Pharmacology. 2008; 81(3): 236-240.
Doi: 10.1159/000113730
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schuligoi Rufina
- Co-Autor*innen der Med Uni Graz
- Heinemann Akos
- Peskar Bernhard
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- Abstract:
- The majority of prostaglandins (PGs) are known to induce intestinal fluid secretion (enteropooling). In contrast, PGD(2) has been demonstrated to inhibit fluid secretion induced by other PGs. This study was aimed to investigate, by the use of selective agonists/antagonists, which type of PGD(2) receptor mediates this inhibitory effect. The DP1 agonist BW245C dose-dependently inhibited the enteropooling effect of 16,16-dimethyl-PGE(2). This inhibition was counteracted by the DP1 antagonist BWA868C. In contrast, the CRTH2 receptor does not seem to be involved in the anti-enteropooling effect of PGD(2), since the selective agonists 13,14-dihydro-15-keto-PGD(2) and 15(R)-15-methyl-PGD(2) were without effect. Therefore, our results suggest that the inhibitory effect of PGD(2) in the small intestine is mediated via activation of the DP1 receptor.
- Find related publications in this database (using NLM MeSH Indexing)
- 16,16-Dimethylprostaglandin E2 - pharmacology
- Animals -
- Female -
- Hydantoins - administration and dosage
- Intestinal Secretions - drug effects
- Intestine, Small - drug effects
- Prostaglandin D2 - analogs and derivatives
- Rats -
- Rats, Sprague-Dawley -
- Receptors, Immunologic - agonists
- Receptors, Prostaglandin - agonists
- Find related publications in this database (Keywords)
- enteropooling
- diarrhea
- prostaglandins
- prostaglandin
- D-2 receptors