Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stojakovic, T; Scharnagl, H; März, W; Winkelmann, BR; Boehm, BO; Schmut, O.
Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion.
CLIN CHIM ACTA. 2007; 382(1-2): 77-81.
Doi: 10.1016/j.cca.2007.03.024
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Stojakovic Tatjana
- Co-Autor*innen der Med Uni Graz
- März Winfried
- Scharnagl Hubert
- Schmut Otto
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- Abstract:
- BACKGROUND: Retinal artery occlusion (RAO) and retinal vein occlusion (RVO) are common causes of severe visual loss and several atherothrombotic risk factors such as hyperlipidemia, diabetes mellitus and arterial hypertension have been associated with these ophthalmic lesions. METHODS: In this retrospective study we investigated 66 patients with RAO, 87 patients with RVO and 405 age- and gender-matched control subjects. Lipoproteins were separated using an ultracentrifugation-precipitation method (beta-quantification) and the levels of lipids and apolipoproteins in VLDL, LDL and HDL particles were measured. RESULTS: After adjusting for the type of occlusion and lipid-lowering medication, patients with RVO and RAO versus controls had significantly higher levels of LDL-cholesterol (3.82+/-1.06, 3.59+/-0.90 and 3.07+/-0.83 mmol/L), LDL-triglycerides (0.39+/-0.14, 0.40+/-0.12 and 0.35+/-0.14 mmol/L) and apolipoprotein B (1.06+/-0.27, 1.05+/-0.26 and 0.84+/-0.21 g/L) in the LDL fraction, respectively. In RAO, LDL-triglycerides were independently associated with retinal vascular occlusion. Interestingly, apolipoprotein AI was elevated in both patient groups compared to controls. The most striking differences were found in lipoprotein(a) where both RVO and RAO patients had significantly higher levels than the control subjects (median values: 320, 290 and 130 mg/L, respectively). CONCLUSION: These findings suggest that disorders in lipoprotein metabolism may contribute to the etiology of retinal vascular occlusions.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Apolipoproteins B - blood
- Case-Control Studies - blood
- Female - blood
- Humans - blood
- Lipoprotein(a) - blood
- Lipoproteins, LDL - blood
- Male - blood
- Middle Aged - blood
- Odds Ratio - blood
- Retinal Artery Occlusion - blood
- Retinal Vein Occlusion - blood
- Retrospective Studies - blood
- Risk Factors - blood
- Triglycerides - blood
- Find related publications in this database (Keywords)
- atherosclerosis
- LDL triglycerides
- lipoprotein(a)
- retinal vascular occlusion
- risk factor