Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sottero, B; Gamba, P; Longhi, M; Robbesyn, F; Abuja, PM; Schaur, RJ; Poli, G; Leonarduzzi, G.
Expression and synthesis of TGFbeta1 is induced in macrophages by 9-oxononanoyl cholesterol, a major cholesteryl ester oxidation product.
Biofactors. 2005; 24(1-4): 209-216.
Doi: 10.1002/biof.5520240125
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Abuja Peter Michael
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- Abstract:
- Within the broad variety of compounds generated via oxidative reactions in low density lipoproteins (LDL) and subsequently found in the atherosclerotic plaque, are aldehydes still esterified to the parent lipid and termed core-aldehydes. The most represented cholesterol core-aldehyde in LDL is 9-oxononanoyl cholesterol (9-ONC), an oxidation product of cholesteryl linoleate. Here we report that 9-ONC, at concentration actually detectable in biological material, significantly up-regulates the expression and the synthesis of the pro-fibrogenic cytokine transforming growth factor beta1 (TGFbeta1) by cultured macrophages. As previously demonstrated for other lipid oxidation products present in LDL, namely a biologically representative mixture of oxysterols and the unesterified aldehyde 4-hydroxynonenal, these effects on TGFbeta1 by 9-ONC further points to LDL lipid oxidation as a powerful source of pro-fibrogenic stimuli.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blotting, Northern -
- Blotting, Western -
- Cell Line -
- Cholesterol - analogs and derivatives
- Enzyme-Linked Immunosorbent Assay - analogs and derivatives
- Gene Expression - drug effects
- Macrophages - metabolism
- Mice - metabolism
- Proteins - genetics
- RNA, Messenger - analysis
- Find related publications in this database (Keywords)
- TGF beta 1
- core-aldehyde
- 9-oxononanoyl cholesterol
- fibrogenesis
- macrophages