Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Horvath, A; Haller, R; Feldbacher, N; Habisch, H; Žukauskaitė, K; Madl, T; Stadlbauer, V.
Probiotic Therapy of Gastrointestinal Symptoms During COVID-19 Infection: A Randomized, Double-Blind, Placebo-Controlled, Remote Study.
Nutrients. 2024; 16(22):
Doi: 10.3390/nu16223970
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- Führende Autor*innen der Med Uni Graz
- Horvath Angela
- Stadlbauer-Köllner Vanessa
- Co-Autor*innen der Med Uni Graz
- Feldbacher Nicole
- Habisch Hansjörg
- Haller Rosa
- Madl Tobias
- Zukauskaite Kristina
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- Abstract:
- BACKGROUND: The novel coronavirus (SARS-CoV-2) led to gastrointestinal manifestations in up to 50% of cases, with diarrhea being common, and probiotics have been suggested as a potential treatment. AIM: This study aimed to assess changes in the microbiome and the effects of a multispecies probiotic in patients with COVID-19 in home quarantine through a fully remote telemedical approach. METHODS: Thirty patients were randomized to receive either the Ecologic AAD probiotic (Winclove Probiotics, Amsterdam, The Netherlands), on the market as OMNi-BiOTiC 10 (Allergosan, Austria), or a placebo for 30 days in a 2:1 ratio. Respiratory and gastrointestinal symptoms were monitored in 2-10-day intervals via online surveys, and five stool samples were collected during the 30-day study period for microbiome and metabolomics analyses. Twenty-four healthy volunteers served as controls. RESULTS: Of the 30 patients, 26 completed this study (10 placebo, 16 probiotic). Patients reported respiratory symptoms and a diminished gastrointestinal quality of life, both of which improved significantly during the study period, irrespective of the intervention. Compared to controls, infected patients showed significant alterations in the fecal microbiome (p = 0.002), including an increase in Bacteroidetes and decreases in Christensenellaceae, Ruminococcaceae, and Gammaproteobacteria, along with metabolomic changes. Probiotic treatment significantly modulated the patients' microbiome beta diversity (p = 0.001) and introduced the Enterococcus faecium W54 strain. Symptoms, COVID-19-related taxa, and the fecal metabolome were not affected by the intervention. CONCLUSIONS: Patients with mild COVID-19 disease in home quarantine exhibited respiratory symptoms, a reduced gastrointestinal quality of life, and changes in the fecal microbiome and metabolome.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Probiotics - therapeutic use, administration & dosage
- Male - administration & dosage
- COVID-19 - therapy
- Female - administration & dosage
- Gastrointestinal Microbiome - administration & dosage
- Middle Aged - administration & dosage
- Double-Blind Method - administration & dosage
- Feces - microbiology
- Adult - administration & dosage
- SARS-CoV-2 - administration & dosage
- Quality of Life - administration & dosage
- Gastrointestinal Diseases - therapy, microbiology
- Aged - administration & dosage
- Quarantine - administration & dosage
- Telemedicine - administration & dosage
- Find related publications in this database (Keywords)
- COVID-19
- probiotic
- microbiome
- patient-reported outcomes
- quality of life
-
Enterococcus faecium