Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fan, KS; Shojaee-Moradie, F; Manoli, A; Baumann, PM; Koehler, G; Edwards, V; Lee, V; Mathieu, C; Mader, JK; Russell-Jones, D, , EASA, Diabetes, Consortium.
The Feasibility of an Experimental Hypobaric Simulation to Evaluate the Safety of Closed-Loop Insulin Delivery Systems in Flight-Related Atmospheric Pressure Changes.
Diabetes Technol Ther. 2025; 27(2):128-133
Doi: 10.1089/dia.2024.0380
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Baumann Petra Martina
- Köhler Gerd
- Mader Julia
- Manoli Antonios
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- Abstract:
- Hybrid closed-loop (HCL) systems remain underexplored within aviation, and as atmospheric pressure changes can independently affect insulin pumps and continuous glucose monitoring readings, this preliminary study assessed the feasibility of HCL safety evaluation, in both fasting and post-prandial states, by using hypobaric chamber to simulate flights. Participants with type 1 diabetes and on HCL were studied: Medtronic Guardian 4-Medtronic 780G-SmartGuard (n = 4), Dexcom G6-Omnipod DASH-Android APS (n = 1), and Dexcom G6-Ypsomed Pump-CamAPS (n = 1). Flight cabin pressures of 550 mmHg and 750 mmHg were simulated in a hypobaric chamber. Seven-hundred-50 glucose measurements were taken, with glucose levels demonstrating a stable decline to 4 mmol/L during fasting. To maintain a tight fasting and post-prandial glucose range across the different pressure settings, the HCL administered insulin as expected. While not demonstrating any apparent issues, repeating flight simulation protocol with other systems, examining longer flights, and undertaking larger, powered randomised controlled trials can confirm their safety in aviation.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Insulin Infusion Systems - administration & dosage
- Diabetes Mellitus, Type 1 - drug therapy, blood
- Feasibility Studies - administration & dosage
- Insulin - administration & dosage
- Atmospheric Pressure - administration & dosage
- Male - administration & dosage
- Blood Glucose - analysis
- Adult - administration & dosage
- Hypoglycemic Agents - administration & dosage, therapeutic use
- Middle Aged - administration & dosage
- Female - administration & dosage
- Aviation - administration & dosage
- Fasting - administration & dosage
- Aerospace Medicine - administration & dosage
- Postprandial Period - administration & dosage
- Blood Glucose Self-Monitoring - administration & dosage
- Find related publications in this database (Keywords)
- closed-loop system
- artificial pancreas
- continuous glucose monitoring
- self-blood glucose monitoring
- aviation